FCGR2A Antibody - PE Conjugated
Référence OASA01888
Conditionnement : 25Tests
Marque : Aviva Systems Biology
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CD32 Antibody - PE Conjugated (OASA01888)
| Datasheets/Manuals | Printable datasheet for CD32 Antibody - PE Conjugated (OASA01888) |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Human |
| Product Format | Lyophilized. Phosphate buffered saline |
| Clonality | Monoclonal |
| Clone | AT10 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | R-PE |
| Application | FC |
| Additional Information | Excitation: 496nm Emission: 578 nm |
| :: | Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line. |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | K562 cell line. |
| Purification | Protein A Purified |
| Specificity | Recognizes human CD32 antigen |
| Application Info | FC: Neat. Use 10 uL of the suggested working dilution to label 106 cells or 100 uL whole blood. |
| Reference | 1. Greenman, J. et al. (1991) Characterisation of a new monoclonal anti-Fc gamma RII antibody, AT10, and its incorporation into a bispecific F(ab')2 derivative for recruitment of cytotoxic effectors. Mol. Immunol. 28: 1243-1254. 2. van den Herik-Oudijk, I. E. et al. (1994) Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes. J. Immunol. 152: 574-585. 3. Lilliehook, I. et al. (1998) Expression of adhesion and Fc gamma - receptors on canine blood eosinophils and neutophils studied by anti-human monoclonal antibodies. Vet. Immunol. Immunopathol. 61: 181-193. 4. Larsson, M. et al. (1997) Human dendritic cells handling of binding, uptake and degradation of free and IgG - immune complexed dinitrophenylated human serum albumin in vitro. Immunology. 90: 138-146. 5. Dutertre, C- A. et al. (2008) A novel subset of NK cells expressing high levels of inhibitory FcgammaRIIB modulating antibody-dependent function. Journal of Leukocyte Biology. 84: 1511-1519. 6. Devriendt, B. et al. (2010) Targeting of Escherichia coli F4 fimbriae to Fcgamma receptors enhances the maturation of porcine dendritic cells. Vet Immunol Immunopathol. 135: 188-98. |
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| Gene Symbol | FCGR2A, FCGR2B, FCGR2C |
| Alias Symbols | CD32, CD32A, CD32B, CD32C, CDw32, Fc fragment of IgG, low affinity II, receptor for (CD32), Fc fragment of IgG, low affinity IIa, receptor (CD32), Fc fragment of IgG, low affinity IIb, receptor (CD32), Fc fragment of IgG, low affinity IIb, receptor for (CD32), Fc fragment of IgG, low affinity IIc, receptor for (CD32), Fc gamma receptor IIb, Fc gamma receptor IIC, Fc gamma receptor RIIa3, Fc gamma RIIb, fc-gamma RII-b, Fc-gamma RII-c, fc-gamma-RIIa, fc-gamma-RIIb, Fc-gamma-RIIc, FCG2, FcGR, FCGR2, FCGR2A1, FCGR2C, fcRII-a, fcRII-b, FcRII-c, FCRIIC, IGFR2, igG Fc receptor II-a, igG Fc receptor II-b, IgG Fc receptor II-c, Immunoglobulin G Fc receptor II, immunoglobulin G Fc receptor II-c, low affinity immunoglobulin gamma Fc region receptor II-a, low affinity immunoglobulin gamma Fc region receptor II-b, Low affinity immunoglobulin gamma Fc region receptor II-c. |
| NCBI Gene Id | 2212|2213|9103 |
| Protein Name | Low affinity immunoglobulin gamma Fc region receptor II-a |
| Description of Target | Human CD32 antigen is a glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII0. CD32 mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes and platelets. It blocks the binding of IgG to Fc gamma RII. |
| Uniprot ID | P12318, P31994, P31995 |
| Protein Accession # | NP_001129691.1 |
| Protein Size (# AA) | 317 |
| Molecular Weight | 40 kDa |
