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> Ganglioside GM2 [127663-77-8]

Ganglioside GM2 [127663-77-8]

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Référence T82340-5mg

Conditionnement : 5mg

Marque : TargetMol

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Ganglioside GM2

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Ganglioside GM2 is a component of the cell membrane's glycosphingolipid bilayer and a human tumor antigen (OFA-I-1). It accumulates and increases in models of Sandhoff disease, Niemann-Pick disease, and Tay-Sachs disease, among others. Ganglioside GM2 binds to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, thereby promoting tumor cell migration and invasion.
Ganglioside GM2
Cas No. 127663-77-8
For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid
Color:White

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Product Introduction

Bioactivity
Description
Ganglioside GM2 is a component of the cell membrane's glycosphingolipid bilayer and a human tumor antigen (OFA-I-1). It accumulates and increases in models of Sandhoff disease, Niemann-Pick disease, and Tay-Sachs disease, among others. Ganglioside GM2 binds to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, thereby promoting tumor cell migration and invasion.
In vitro
Ganglioside GM2 (25 μM, 24 hours) significantly enhances the migration and invasion capabilities of SK-RC-45 tumor cells [1].
Chemical Properties
Molecular Weight1384.68
FormulaC67H121N3O26
Cas No.127663-77-8
SmilesO([C@@]1(C(O)=O)O[C@@]([C@@H]([C@@H](CO)O)O)([C@H](NC(C)=O)[C@@H](O)C1)15)[C@H]2[C@@H](O[C@H]3[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)[C@@H](CO)O[C@@H](O[C@@H]4[C@@H](CO)O[C@@H](OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@@H](/C=C/CCCCCCCCCCCCC)O)[C@H](O)[C@H]4O)[C@@H]2O
Storage & Solubility Information
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (7.22 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.7222 mL3.6109 mL7.2219 mL36.1094 mL
5 mM0.1444 mL0.7222 mL1.4444 mL7.2219 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.