GAP43 Antibody
Référence MBS8582246-0,1mL-HRP
Conditionnement : 0.1mL(HRP)
Marque : MyBiosource
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GAP43 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582246MBS8582246 is an antibody targeting GAP43. Also known as GAP43 Antibody. Reactive in Human, Mouse, Rat, Bovine, Chicken, Monkey, Zebrafish. Host: Rabbit. Rabbit polyclonal antibody to GAP43 More details
Product Overview
Online Datasheet in PDFProduct Name
GAP43, Polyclonal Antibody
Full Product Name
GAP43 Antibody
Product Gene Name
anti-GAP43 antibody
Product Synonym Names
Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Chicken, Monkey, Zebrafish
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of GAP43 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
24,803 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (115342151..115440334). Location: 3q13.1-q13.2
OMIM
162060
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GAP43. The exact sequence is proprietary.
Product Categories/Family for anti-GAP43 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GAP43 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-GAP43 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-GAP43 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for GAP43. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
neuromodulin isoform 1
NCBI Official Synonym Full Names
growth associated protein 43
NCBI Official Symbol
GAP43
NCBI Official Synonym Symbols
B-50; PP46
UniProt Protein Name
Neuromodulin
UniProt Synonym Protein Names
Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46
Protein Family
Neuromodulin
UniProt Gene Name
GAP43
UniProt Entry Name
NEUM_HUMAN
NCBI Protein Information
neuromodulin; protein F1; neural phosphoprotein B-50; growth-associated protein 43; axonal membrane protein GAP-43; calmodulin-binding protein P-57; nerve growth-related peptide GAP43; neuron growth-associated protein 43
NCBI Summary for GAP43
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for GAP43
GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 3q13.31
Cellular Component: filopodium membrane; axon; cytoplasm; postsynaptic density; plasma membrane; cell junction
Molecular Function: calmodulin binding; protein binding
Biological Process: cell fate commitment; glial cell differentiation; tissue regeneration; regulation of growth; axon choice point recognition; protein kinase C activation; response to wounding; regulation of filopodium formation
Show more Protein type: Cell surface
Chromosomal Location of Human Ortholog: 3q13.31
Cellular Component: filopodium membrane; axon; cytoplasm; postsynaptic density; plasma membrane; cell junction
Molecular Function: calmodulin binding; protein binding
Biological Process: cell fate commitment; glial cell differentiation; tissue regeneration; regulation of growth; axon choice point recognition; protein kinase C activation; response to wounding; regulation of filopodium formation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-GAP43 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Glial Cell Differentiation Pathway antibodies | Glial Cell Differentiation Pathway Diagram |
| N-cadherin Signaling Events Pathway antibodies | N-cadherin Signaling Events Pathway Diagram |
| Spinal Cord Injury Pathway antibodies | Spinal Cord Injury Pathway Diagram |
Diseases associated with anti-GAP43 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Nervous System Diseases Antibodies | >103 publications with GAP43 and Nervous System Diseases |
| Disease Models, Animal Antibodies | >52 publications with GAP43 and Disease Models, Animal |
| Brain Diseases Antibodies | >43 publications with GAP43 and Brain Diseases |
| Cardiovascular Diseases Antibodies | >35 publications with GAP43 and Cardiovascular Diseases |
| Neoplasms Antibodies | >29 publications with GAP43 and Neoplasms |
| Death Antibodies | >27 publications with GAP43 and Death |
| Heart Diseases Antibodies | >24 publications with GAP43 and Heart Diseases |
| Inflammation Antibodies | >19 publications with GAP43 and Inflammation |
| Nerve Degeneration Antibodies | >18 publications with GAP43 and Nerve Degeneration |
| Pain Antibodies | >18 publications with GAP43 and Pain |
Organs/Tissues associated with anti-GAP43 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Nerve Antibodies | >231 publications with GAP43 and Nerve |
| Brain Antibodies | >194 publications with GAP43 and Brain |
| Embryonic Tissue Antibodies | >27 publications with GAP43 and Embryonic Tissue |
| Eye Antibodies | >26 publications with GAP43 and Eye |
| Bone Antibodies | >15 publications with GAP43 and Bone |
| Vascular Antibodies | >12 publications with GAP43 and Vascular |
| Lung Antibodies | >2 publications with GAP43 and Lung |
| Connective Tissue Antibodies | >1 publications with GAP43 and Connective Tissue |