Glucose-Dependent Insulinotropic Polypeptide (human) (Gastric Inhibitory Polypeptide)
Référence MBS634972-5x1mg
Conditionnement : 5x1mg
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Glucose-Dependent Insulinotropic Polypeptide (GIP) Human Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS634972MBS634972 is a protein targeting GIP. Also known as Glucose-Dependent Insulinotropic Polypeptide (human) (Gastric Inhibitory Polypeptide). Reactive in Human. Host: Synthetic peptide. More details
Product Overview
Product Name
Glucose-Dependent Insulinotropic Polypeptide (GIP), Protein
Full Product Name
Glucose-Dependent Insulinotropic Polypeptide (human) (Gastric Inhibitory Polypeptide)
Product Gene Name
GIP protein
Host
Synthetic peptide
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder.
Purity/Purification
Highly Purified
~95%. Purified by HPLC.
~95%. Purified by HPLC.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
17,108 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (47035918..47045955, complement). Location: 17q21.3-q22
OMIM
137240
Sequence (linear)
Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln
Product Categories/Family for GIP protein
Other Notes
Small volumes of GIP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for GIP. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
gastric inhibitory polypeptide preproprotein
NCBI Official Synonym Full Names
gastric inhibitory polypeptide
NCBI Official Symbol
GIP
UniProt Protein Name
Gastric inhibitory polypeptide
UniProt Synonym Protein Names
Glucose-dependent insulinotropic polypeptide; Incretin hormone
Protein Family
Copia protein
UniProt Gene Name
GIP
UniProt Synonym Gene Names
GIP
UniProt Entry Name
GIP_HUMAN
NCBI Protein Information
gastric inhibitory polypeptide; incretin hormone; glucose-dependent insulinotropic polypeptide
NCBI Summary for GIP
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for GIP
GIP: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. Belongs to the glucagon family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q21.3-q22
Cellular Component: extracellular space; cell soma; endoplasmic reticulum lumen; extracellular region
Molecular Function: hormone activity
Biological Process: response to drug; response to peptide hormone stimulus; adult locomotory behavior; positive regulation of insulin secretion; female pregnancy; signal transduction; sensory perception of pain; response to amino acid stimulus; response to lipid; endocrine pancreas development; response to organic cyclic substance; memory; response to starvation; response to selenium ion; cellular protein metabolic process; response to glucose stimulus; response to axon injury; regulation of insulin secretion
Show more Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q21.3-q22
Cellular Component: extracellular space; cell soma; endoplasmic reticulum lumen; extracellular region
Molecular Function: hormone activity
Biological Process: response to drug; response to peptide hormone stimulus; adult locomotory behavior; positive regulation of insulin secretion; female pregnancy; signal transduction; sensory perception of pain; response to amino acid stimulus; response to lipid; endocrine pancreas development; response to organic cyclic substance; memory; response to starvation; response to selenium ion; cellular protein metabolic process; response to glucose stimulus; response to axon injury; regulation of insulin secretion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with GIP protein
| Reference Product | PubMed Publications |
|---|---|
| GIPR protein | >82 publications with GIP and GIPR |
| DPP4 protein | >48 publications with GIP and DPP4 |
| BAX protein | >5 publications with GIP and BAX |
| GATA4 protein | >3 publications with GIP and GATA4 |
| RETN protein | >1 publications with GIP and RETN |
Pathways associated with GIP protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Class B/2 (Secretin Family Receptors) Pathway antibodies | Class B/2 (Secretin Family Receptors) Pathway Diagram |
| G Alpha (s) Signalling Events Pathway antibodies | G Alpha (s) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Glucagon-type Ligand Receptors Pathway antibodies | Glucagon-type Ligand Receptors Pathway Diagram |
| Incretin Synthesis, Secretion, And Inactivation Pathway antibodies | Incretin Synthesis, Secretion, And Inactivation Pathway Diagram |
| Insulin Secretion Pathway antibodies | Insulin Secretion Pathway Diagram |
| Metabolism Of Proteins Pathway antibodies | Metabolism Of Proteins Pathway Diagram |
| Peptide Hormone Metabolism Pathway antibodies | Peptide Hormone Metabolism Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
Diseases associated with GIP protein
| Disease Name | Pubmed Publications |
|---|---|
| Diabetes Mellitus, Type 2 Antibodies | >403 publications with GIP and Diabetes Mellitus, Type 2 |
| Neoplasms Antibodies | >162 publications with GIP and Neoplasms |
| Weight Loss Antibodies | >93 publications with GIP and Weight Loss |
| Diabetes Complications Antibodies | >77 publications with GIP and Diabetes Complications |
| Weight Gain Antibodies | >56 publications with GIP and Weight Gain |
| Neurologic Manifestations Antibodies | >42 publications with GIP and Neurologic Manifestations |
| Carcinoma Antibodies | >41 publications with GIP and Carcinoma |
| Hyperplasia Antibodies | >40 publications with GIP and Hyperplasia |
| Kidney Diseases Antibodies | >29 publications with GIP and Kidney Diseases |
| Hypertension Antibodies | >23 publications with GIP and Hypertension |
Organs/Tissues associated with GIP protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Intestine Antibodies | >446 publications with GIP and Intestine |
| Stomach Antibodies | >152 publications with GIP and Stomach |