Hisne H2A Acetyl

Référence MBS8535044-0,1mL-APC

Conditionnement : 0.1mL(APC)

Marque : MyBiosource

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Hisne H2A Acetyl (H2AFX) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8535044

MBS8535044 is an antibody targeting H2afx. Also known as Hisne H2A Acetyl. Reactive in Broad mammalian, Zebrafish, Drosophila, Xenopus and C. elegans. Host: Rabbit. More details

Product Overview

Online Datasheet in PDF
Product Name
Hisne H2A Acetyl (H2afx), Polyclonal Antibody
Full Product Name
Hisne H2A Acetyl
Product Gene Name
anti-H2afx antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Broad mammalian, Zebrafish, Drosophila, Xenopus and C. elegans
Purity/Purification
Immunogen affinity purified
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
15,143 Da
3D Structure
ModBase 3D Structure for P27661
Immunogen
Peptide
Storage Buffer
1*TBS (pH7.4), 1% BSA, 40% Glycerol.
Preservative
0.05% Sodium Azide.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-H2afx antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Other Notes

Small volumes of anti-H2afx antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for H2afx. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
histone H2AX
NCBI Official Synonym Full Names
H2A histone family, member X
NCBI Official Symbol
H2afx
NCBI Official Synonym Symbols
H2ax; H2A.X; AW228881; Hist5-2ax; gammaH2ax
UniProt Protein Name
Histone H2AX
UniProt Synonym Protein Names
Histone H2A.X
UniProt Gene Name
H2afx
UniProt Synonym Gene Names
H2a.x; H2ax; Hist5-2ax; H2a/x
NCBI Protein Information
histone H2AX

NCBI Summary for H2afx

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
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UniProt Comments for H2afx

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-H2afx antibody

 Products by Pathway  Pathway Diagram
 ATM Mediated Phosphorylation Of Repair Proteins Pathway antibodies  ATM Mediated Phosphorylation Of Repair Proteins Pathway Diagram
 ATM Mediated Response To DNA Double-strand Break Pathway antibodies  ATM Mediated Response To DNA Double-strand Break Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway antibodies  Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram

Diseases associated with anti-H2afx antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >378 publications with H2afx and Neoplasms
 Ataxia Antibodies  >252 publications with H2afx and Ataxia
 Carcinoma Antibodies  >122 publications with H2afx and Carcinoma
 Drug Toxicity Antibodies  >84 publications with H2afx and Drug Toxicity
 Skin Diseases Antibodies  >68 publications with H2afx and Skin Diseases
 Breast Neoplasms Antibodies  >66 publications with H2afx and Breast Neoplasms
 Gastrointestinal Diseases Antibodies  >49 publications with H2afx and Gastrointestinal Diseases
 Nervous System Diseases Antibodies  >45 publications with H2afx and Nervous System Diseases
 Lung Neoplasms Antibodies  >44 publications with H2afx and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >42 publications with H2afx and Neoplasms, Experimental

Organs/Tissues associated with anti-H2afx antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >63 publications with H2afx and Lung
 Brain Antibodies  >29 publications with H2afx and Brain
 Bone Antibodies  >23 publications with H2afx and Bone
 Liver Antibodies  >15 publications with H2afx and Liver
 Testis Antibodies  >11 publications with H2afx and Testis
 Heart Antibodies  >11 publications with H2afx and Heart
 Intestine Antibodies  >10 publications with H2afx and Intestine
 Eye Antibodies  >9 publications with H2afx and Eye
 Embryonic Tissue Antibodies  >9 publications with H2afx and Embryonic Tissue
 Ovary Antibodies  >7 publications with H2afx and Ovary