HOMER1 Antibody - Biotin Conjugated
Référence OACA01019
Conditionnement : 100ug
Marque : Aviva Systems Biology
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HOMER1 Antibody - Biotin Conjugated (OACA01019)
| Datasheets/Manuals | Printable datasheet for HOMER1 Antibody - Biotin Conjugated (OACA01019) (OACA01019) |
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| Predicted Species Reactivity | Human |
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| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Biotin |
| Application | ELISA |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Homer protein homolog 1 protein (1-354AA) |
| Purification | Protein G Purified |
| Purity | Caprylic Acid Ammonium Sulfate Precipitation purified |
| Storage Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Reference | [1] Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.'Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.Neuron 21:707-716(1998) [2] Cloning and molecular characterization of a human cDNA Syn47 showing strong homology to the cDNA of the rat protein Homer.'Nickels A., Heckel D., Sahin U., Tuereci O., Koch B., Meese E., Pfreundschuh M., Montenarh M.Submitted (JUL-1998) [3] Multiple splice isoforms of the HOMER1 gene.'Klugmann M., Leichtlein C.B., Klaussner B.K., During M.J.Submitted (DEC-2002) |
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| Gene Symbol | HOMER1 |
| Gene Full Name | homer scaffold protein 1 |
| Alias Symbols | HOMER;homer homolog 1;homer protein homolog 1;homer scaffolding protein 1;homer, neuronal immediate early gene, 1;homer-1;HOMER1A;HOMER1B;HOMER1C;SYN47;Ves-1. |
| NCBI Gene Id | 9456 |
| Protein Name | Homer protein homolog 1 |
| Description of Target | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). |
| Uniprot ID | Q86YM7 |
| Protein Accession # | NP_001264006.1; NP_001264007.1; NP_004263.1 |
| Nucleotide Accession # | NM_001277077.1; NM_001277078.1; NM_004272.4 |
