HRP-Linked Polyclonal Antibody to Alpha-2-Macroglobulin (a2M)
Référence MBS2050557-0,5mL
Conditionnement : 0.5mL
Marque : MyBiosource
Alpha-2-Macroglobulin (a2M) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2050557SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2050557 is an antibody targeting a2M. Also known as HRP-Linked Polyclonal Antibody to Alpha-2-Macroglobulin (a2M). Reactive in Mouse, Rat. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Alpha-2-Macroglobulin (a2M), Polyclonal Antibody
Full Product Name
HRP-Linked Polyclonal Antibody to Alpha-2-Macroglobulin (a2M)
Product Gene Name
anti-a2M antibody
Product Synonym Names
A2MG; A2mg; CPAMD5; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Concentration
500ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: a2M (MBS2006946)
HRP Conjugated Antibody: a2M (MBS2050557)
HRP Conjugated Antibody: a2M (MBS2050557)
Matching Pairs
HRP Conjugated Antibody: a2M (MBS2050557)
Immunogen: a2M (MBS2010061)
Immunogen: a2M (MBS2010061)
Molecular Weight
163,291 Da
OMIM
M11313 mRNA
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
a2M (Val574~Pro734)
Conjugation
HRP
Cross Reactivity
Rat
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2006946
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-a2M antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
Other Notes
Small volumes of anti-a2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for a2M. It may not necessarily be applicable to this product.
NCBI Official Full Name
alpha-2-macroglobulin
NCBI Official Synonym Full Names
alpha-2-macroglobulin
NCBI Official Symbol
A2M
NCBI Official Synonym Symbols
A2MD; CPAMD5; FWP007; S863-7
UniProt Protein Name
Alpha-2-macroglobulin
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Protein Family
Alpha-2-macroglobulin
UniProt Gene Name
A2M
UniProt Synonym Gene Names
CPAMD5; Alpha-2-M
NCBI Protein Information
alpha-2-macroglobulin
NCBI Summary for a2M
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Show more UniProt Comments for a2M
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-a2M antibody
| Reference Product | PubMed Publications |
|---|---|
| APP antibody | >18 publications with a2M and APP |
| ALB antibody | >6 publications with a2M and ALB |
| APOA1 antibody | >4 publications with a2M and APOA1 |
| TGFB1 antibody | >3 publications with a2M and TGFB1 |
| SERPINF2 antibody | >2 publications with a2M and SERPINF2 |
| PLG antibody | >2 publications with a2M and PLG |
| SERPINA1 antibody | >2 publications with a2M and SERPINA1 |
| KLK3 antibody | >1 publications with a2M and KLK3 |
Pathways associated with anti-a2M antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Degradation Of The Extracellular Matrix Pathway antibodies | Degradation Of The Extracellular Matrix Pathway Diagram |
| Extracellular Matrix Organization Pathway antibodies | Extracellular Matrix Organization Pathway Diagram |
| Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies | Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram |
| HDL-mediated Lipid Transport Pathway antibodies | HDL-mediated Lipid Transport Pathway Diagram |
| Hemostasis Pathway antibodies | Hemostasis Pathway Diagram |
| IL6-mediated Signaling Events Pathway antibodies | IL6-mediated Signaling Events Pathway Diagram |
| Intrinsic Pathway Of Fibrin Clot Formation antibodies | Intrinsic Pathway Of Fibrin Clot Formation Diagram |
Diseases associated with anti-a2M antibody
| Disease Name | Pubmed Publications |
|---|---|
| Nervous System Diseases Antibodies | >100 publications with a2M and Nervous System Diseases |
| Mental Disorders Antibodies | >86 publications with a2M and Mental Disorders |
| Alzheimer Disease Antibodies | >84 publications with a2M and Alzheimer Disease |
| Immune System Diseases Antibodies | >45 publications with a2M and Immune System Diseases |
| Inflammation Antibodies | >40 publications with a2M and Inflammation |
| Liver Diseases Antibodies | >18 publications with a2M and Liver Diseases |
| Lung Diseases Antibodies | >15 publications with a2M and Lung Diseases |
| Necrosis Antibodies | >14 publications with a2M and Necrosis |
| Fibrosis Antibodies | >13 publications with a2M and Fibrosis |
| Disease Models, Animal Antibodies | >12 publications with a2M and Disease Models, Animal |
Organs/Tissues associated with anti-a2M antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >152 publications with a2M and Blood |
| Liver Antibodies | >44 publications with a2M and Liver |
| Brain Antibodies | >37 publications with a2M and Brain |
| Vascular Antibodies | >21 publications with a2M and Vascular |
| Lung Antibodies | >14 publications with a2M and Lung |
| Prostate Antibodies | >11 publications with a2M and Prostate |
| Heart Antibodies | >10 publications with a2M and Heart |
| Bone Antibodies | >9 publications with a2M and Bone |
| Ovary Antibodies | >7 publications with a2M and Ovary |
| Kidney Antibodies | >7 publications with a2M and Kidney |


