Human Ghrelin
Référence MBS142690-20mg
Conditionnement : 20mg
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Ghrelin (GHRL) Human Synthetic Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142690Description: Ghrelin Human contains 28 amino acids and a total molecular mass of 3370.9 Dalton and a molecular formula of C149H249N47O42.The GHRL is purified by proprietary chromatographic techniques. More details
Product Overview
Online Datasheet in PDFProduct Name
Ghrelin (GHRL), Synthetic Protein
Full Product Name
Human Ghrelin
Product Gene Name
GHRL synthetic protein
Product Synonym Names
Appetite-regulating hormone precursor, Growth hormone secretagogue, Growth hormone-releasing peptide, GHRP, Motilin-related peptide, M46 protein, Ghrelin, Obestatin, MTLRP.
Sequence
Gly-Ser-Se r(n-octano yl)-Phe-Le u-Ser-Pro- Glu-His-Gl n-Arg-Val- Gln-Gln-Ar g-Lys-Glu- Ser-Lys-Ly s-Pro-Pro- Ala-Lys-Le u-Gln-Pro- Arg-OH
Form/Format
Lyophilized without additives
Purity/Purification
Greater than 98.0% as determined by
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Preparation and Storage
Store the lyophilized Ghrelin at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted GHRL can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
OMIM
605353
Physical Appearance
Sterile Filtered Yellowish lyophilized (freeze-dried) powder that may appear as a gel form
Solubility
Add deionized water to a working concentration approximately 0.5 mg/1ml and let the lyophilized pellet dissolve completely.
Product Categories/Family for GHRL synthetic protein
Hormones; Hormones; Peptide Hormones
Other Notes
Small volumes of GHRL synthetic protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for GHRL purchase
MBS142690 is a synthetic protein targeting GHRL. Also known as Human Ghrelin.
Additional Details
NCBI/Uniprot data below describe general gene information for GHRL. It may not necessarily be applicable to this product.
NCBI Official Full Name
appetite-regulating hormone isoform 2 preproprotein
NCBI Official Synonym Full Names
ghrelin/obestatin prepropeptide
NCBI Official Symbol
GHRL
NCBI Official Synonym Symbols
MTLRP
UniProt Protein Name
Appetite-regulating hormone
UniProt Synonym Protein Names
Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46Cleaved into the following 3 chains:Ghrelin-27; Ghrelin-28; Ghrelin; Obestatin
Protein Family
Appetite-regulating hormone
UniProt Gene Name
GHRL
UniProt Synonym Gene Names
MTLRP; Ghrelin
UniProt Entry Name
GHRL_HUMAN
NCBI Protein Information
appetite-regulating hormone; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin preprohormone; growth hormone-releasing peptide; motilin-related peptide; prepro-appetite regulatory hormone
NCBI Summary for GHRL
This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]
Show more UniProt Comments for GHRL
ghrelin: a hormone that binds to the growth hormone secretagogue receptor type 1 (GHSR). Secreted by the stomach
Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation; Cell cycle regulation; Apoptosis
Chromosomal Location of Human Ortholog: 3p26-p25
Cellular Component: extracellular space; endoplasmic reticulum lumen; axon; extracellular region
Molecular Function: growth hormone-releasing hormone activity; G-protein-coupled receptor binding; ghrelin receptor binding; protein tyrosine kinase activator activity
Biological Process: cortisol secretion; negative regulation of circadian sleep/wake cycle, REM sleep; positive regulation of cortisol secretion; hormone-mediated signaling; activation of MAPK activity; response to hormone stimulus; negative regulation of interleukin-6 biosynthetic process; decidualization; positive regulation of multicellular organism growth; positive regulation of adrenocorticotropic hormone secretion; negative regulation of insulin secretion; growth hormone secretion; elevation of cytosolic calcium ion concentration; negative regulation of locomotion; positive regulation of appetite; dendrite development; negative regulation of tumor necrosis factor biosynthetic process; positive regulation of circadian sleep/wake cycle, non-REM sleep; regulation of response to food; gastric acid secretion; positive regulation of insulin secretion; glucose metabolic process; adult feeding behavior; negative regulation of interleukin-1 beta production; regulation of cell proliferation; positive regulation of growth hormone secretion; positive regulation of synaptogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cellular protein metabolic process; response to estrogen stimulus; negative regulation of inflammatory response; cartilage development; actin polymerization and/or depolymerization; negative regulation of endothelial cell proliferation; regulation of excitatory postsynaptic membrane potential; negative regulation of apoptosis
Disease: Obesity
Show more Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation; Cell cycle regulation; Apoptosis
Chromosomal Location of Human Ortholog: 3p26-p25
Cellular Component: extracellular space; endoplasmic reticulum lumen; axon; extracellular region
Molecular Function: growth hormone-releasing hormone activity; G-protein-coupled receptor binding; ghrelin receptor binding; protein tyrosine kinase activator activity
Biological Process: cortisol secretion; negative regulation of circadian sleep/wake cycle, REM sleep; positive regulation of cortisol secretion; hormone-mediated signaling; activation of MAPK activity; response to hormone stimulus; negative regulation of interleukin-6 biosynthetic process; decidualization; positive regulation of multicellular organism growth; positive regulation of adrenocorticotropic hormone secretion; negative regulation of insulin secretion; growth hormone secretion; elevation of cytosolic calcium ion concentration; negative regulation of locomotion; positive regulation of appetite; dendrite development; negative regulation of tumor necrosis factor biosynthetic process; positive regulation of circadian sleep/wake cycle, non-REM sleep; regulation of response to food; gastric acid secretion; positive regulation of insulin secretion; glucose metabolic process; adult feeding behavior; negative regulation of interleukin-1 beta production; regulation of cell proliferation; positive regulation of growth hormone secretion; positive regulation of synaptogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cellular protein metabolic process; response to estrogen stimulus; negative regulation of inflammatory response; cartilage development; actin polymerization and/or depolymerization; negative regulation of endothelial cell proliferation; regulation of excitatory postsynaptic membrane potential; negative regulation of apoptosis
Disease: Obesity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with GHRL synthetic protein
| Reference Product | PubMed Publications |
|---|---|
| GHSR synthetic protein | >28 publications with GHRL and GHSR |
| NPY synthetic protein | >12 publications with GHRL and NPY |
| LEP synthetic protein | >11 publications with GHRL and LEP |
| CCK synthetic protein | >5 publications with GHRL and CCK |
| GHRH synthetic protein | >3 publications with GHRL and GHRH |
| AGRP synthetic protein | >3 publications with GHRL and AGRP |
| GCG synthetic protein | >2 publications with GHRL and GCG |
| IGF1 synthetic protein | >1 publications with GHRL and IGF1 |
| GPR39 synthetic protein | >1 publications with GHRL and GPR39 |
Pathways associated with GHRL synthetic protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies | Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| G Alpha (q) Signalling Events Pathway antibodies | G Alpha (q) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies | Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram |
| Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies | Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram |
| Metabolism Of Proteins Pathway antibodies | Metabolism Of Proteins Pathway Diagram |
| Peptide Hormone Metabolism Pathway antibodies | Peptide Hormone Metabolism Pathway Diagram |
Diseases associated with GHRL synthetic protein
| Disease Name | Pubmed Publications |
|---|---|
| Obesity Antibodies | >53 publications with GHRL and Obesity |
| Insulin Resistance Antibodies | >18 publications with GHRL and Insulin Resistance |
| Nervous System Diseases Antibodies | >13 publications with GHRL and Nervous System Diseases |
| Weight Gain Antibodies | >12 publications with GHRL and Weight Gain |
| Inflammation Antibodies | >10 publications with GHRL and Inflammation |
| Cachexia Antibodies | >7 publications with GHRL and Cachexia |
| Kidney Diseases Antibodies | >5 publications with GHRL and Kidney Diseases |
| Heart Diseases Antibodies | >5 publications with GHRL and Heart Diseases |
| Breast Neoplasms Antibodies | >5 publications with GHRL and Breast Neoplasms |
| Necrosis Antibodies | >5 publications with GHRL and Necrosis |
Organs/Tissues associated with GHRL synthetic protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >80 publications with GHRL and Blood |
| Stomach Antibodies | >27 publications with GHRL and Stomach |
| Brain Antibodies | >23 publications with GHRL and Brain |
| Connective Tissue Antibodies | >11 publications with GHRL and Connective Tissue |
| Intestine Antibodies | >4 publications with GHRL and Intestine |
| Prostate Antibodies | >2 publications with GHRL and Prostate |
| Embryonic Tissue Antibodies | >1 publications with GHRL and Embryonic Tissue |
| Lung Antibodies | >1 publications with GHRL and Lung |