Human MAP2K3 Antibody : APC (Phospho-S189/S207)
Référence OAAQ00147-10tests
Conditionnement : 10Tests
Marque : Aviva Systems Biology
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Human MAP2K3 Antibody : APC (Phospho-S189/S207)
Human MAP2K3 Antibody : APC (Phospho-S189/S207) (OAAQ00147)
| Datasheets/Manuals | Printable datasheet for OAAQ00147 |
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| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | MKK3S189MKK6S207-D3 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | APC: Allophycocyanin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser189 of human phospho MKK3 and Ser207 of human phospho MKK6. |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-S189/S207 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | 1. Derijard, B. et al. (1995) Science 267, 682-685. 2. Raingeaud, J. et al. (1995) J Biol Chem 270, 7420-6. 3. Sluss, H.K. et al. (1994) Mol. Cell. Biol. 14, 8376-8384. 4. Raingeaud, J. et al. (1996) Mol. Cell. Biol. 16(3), 1247-1255. 5. Han, J. et al. (1996) J. Biol. Chem. 271, 2886-2891. |
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| Gene Symbol | MAP2K3 |
| Gene Full Name | mitogen-activated protein kinase kinase 3 |
| Alias Symbols | MEK3, MKK3, MAPKK3, PRKMK3, SAPKK2, SAPKK-2 |
| NCBI Gene Id | 5606 |
| Protein Name | dual specificity mitogen-activated protein kinase kinase 3 |
| Description of Target | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. |
| Uniprot ID | P46734 |
| Protein Accession # | NP_001303261.1 |
| Nucleotide Accession # | NM_001316332.1 |
