Human MAPK14 Antibody : APC (Phospho-Thr180/Tyr182)
Référence OAAQ00023-100tests
Conditionnement : 100Tests
Marque : Aviva Systems Biology
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Human MAPK14 Antibody : APC (Phospho-Thr180/Tyr182)
Human MAPK14 Antibody : APC (Phospho-Thr180/Tyr182) (OAAQ00023)
| Datasheets/Manuals | Printable datasheet for OAAQ00023 |
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| Tested Species Reactivity | Human, Mouse, Rat |
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| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | P38T180Y182-E3 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | APC: Allophycocyanin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr180/Tyr182 of human phospho p38 MAPK. |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Thr180/Tyr182 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | (1) Corre I, Paris F, Huot J. (2017) Oncotarget. 8:55684-55714. (2) Tudor C, Marchese FP, Hitti E, et al. (2009) FEBS Letters. 583: 1933-1938. |
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| Gene Symbol | MAPK14 |
| Gene Full Name | mitogen-activated protein kinase 14 |
| Alias Symbols | RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA |
| NCBI Gene Id | 1432 |
| Protein Name | mitogen-activated protein kinase 14 |
| Description of Target | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Uniprot ID | Q16539 |
| Protein Accession # | NP_001306.1 |
| Nucleotide Accession # | NM_001315.2 |
