GA105611G1, Neurotrypsin gRNA vector 1 in pCas-Guide-GFP-CRISPRa
GA105611G2, Neurotrypsin gRNA vector 2 in pCas-Guide-GFP-CRISPRa
GA105611G3, Neurotrypsin gRNA vector 3 in pCas-Guide-GFP-CRISPRa
1 CRISPRa-Enhancer vector, SKU GE100056
1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer
These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). provided by RefSeq, Jul 2017
PRSS12 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
1 kit
Citations
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