Human PLCG2 Antibody : PE (Phospho-Tyr759)
Référence OAAQ00028-100tests
Conditionnement : 100Tests
Marque : Aviva Systems Biology
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
Human PLCG2 Antibody : PE (Phospho-Tyr759)
Human PLCG2 Antibody : PE (Phospho-Tyr759) (OAAQ00028)
| Datasheets/Manuals | Printable datasheet for OAAQ00028 |
|---|
| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | PLCG2Y759-G3 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | PE: Phycoerythrin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCγ2. |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Tyr759 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | Rodriguez R, Matsuda M, Perisic O, Bravo J, Paul A, Jones NP, Light Y, Swann K, Williams RL, and Katan M. (2001) Journal of Biological Chemistry. 276:47982-47992. Zhou Q, Lee G, Brady J et al. (2012) American Journal of Human Genetics. 4:713-720 |
|---|---|
| Gene Symbol | PLCG2 |
| Gene Full Name | phospholipase C gamma 2 |
| Alias Symbols | FCAS3, APLAID, PLC-IV, PLC-gamma-2 |
| NCBI Gene Id | 5336 |
| Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 |
| Description of Target | The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. |
| Uniprot ID | P16885 |
| Protein Accession # | NP_002652.2 |
| Nucleotide Accession # | NM_002661.4 |
