Human SRC Antibody : PE (Phospho-Tyr416)
Référence OAAQ00069-100tests
Conditionnement : 100Tests
Marque : Aviva Systems Biology
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Human SRC Antibody : PE (Phospho-Tyr416)
Human SRC Antibody : PE (Phospho-Tyr416) (OAAQ00069)
| Datasheets/Manuals | Printable datasheet for OAAQ00069 |
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| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | SrcY416-C4 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | PE: Phycoerythrin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr416 of human phospho Src |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Tyr416 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | (1) Src family kinases, key regulators of signal transduction. Parsons SJ, Parsons JT Oncogene. 2004 Oct 18; 23(48):7906-9. (2) Src protein-tyrosine kinase structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2004 Nov 26; 324(4):1155-64. (3) Cohen GB, Ren R, Baltimore D. Modular binding domains in signal transduction proteins. Cell. 1995;80:237-248. |
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| Gene Symbol | SRC |
| Gene Full Name | SRC proto-oncogene, non-receptor tyrosine kinase |
| Alias Symbols | ASV, SRC1, THC6, c-SRC, p60-Src |
| NCBI Gene Id | 6714 |
| Protein Name | proto-oncogene tyrosine-protein kinase Src |
| Description of Target | This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. |
| Uniprot ID | P12931 |
| Protein Accession # | NP_005408.1 |
| Nucleotide Accession # | NM_005417.4 |
