Iberdomide [1323403-33-3]
Référence HY-101291-1ml
Conditionnement : 10mM/1mL
Marque : MedChemExpress
Iberdomide (CC-220) est un modulateur de cereblon (CRBN) avec une valeur IC50 de 60 nM.
Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities.
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Iberdomide Chemical Structure
CAS No. : 1323403-33-3
This product is a controlled substance and not for sale in your territory.
Based on 8 publication(s) in Google Scholar
Description |
Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities[1][2]. |
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In Vitro |
Iberdomide (CC-220; 0.01, 0.1, 1, 10 μM; 72-96 hrs) has antiproliferative effects in a panel of multiple myeloma (MM) cell lines (EJM, H929, KMS11, KMS128M, KMS12PE, MM1.S, MM1.R, RPM-8226, U266 cells) across a range of concentrations[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Iberdomide (CC-220; 10 mg/kg; oral gavage) after 6 or 24 hours causes higher hCRBN expression in hC343 splenocytes correlated to deeper IKZF1/3 downregulation in WT (C57BL/6), hC123, or-343, (representing two different transgenic founder lines expressing hCRBN) and mCrbn-/- mice[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
449.50 |
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Formule |
C25H27N3O5 |
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CAS No. |
1323403-33-3 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C([C@@H](N(CC1=C2C=CC=C1OCC3=CC=C(CN4CCOCC4)C=C3)C2=O)CC5)NC5=O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 125 mg/mL (278.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
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Working solution concentration:
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Method for preparing stock solution:
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Method for preparing in vivo working solution for animal experiments: Take
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.2247 mL | 11.1235 mL | 22.2469 mL | 55.6174 mL |
5 mM | 0.4449 mL | 2.2247 mL | 4.4494 mL | 11.1235 mL | |
10 mM | 0.2225 mL | 1.1123 mL | 2.2247 mL | 5.5617 mL | |
15 mM | 0.1483 mL | 0.7416 mL | 1.4831 mL | 3.7078 mL | |
20 mM | 0.1112 mL | 0.5562 mL | 1.1123 mL | 2.7809 mL | |
25 mM | 0.0890 mL | 0.4449 mL | 0.8899 mL | 2.2247 mL | |
30 mM | 0.0742 mL | 0.3708 mL | 0.7416 mL | 1.8539 mL | |
40 mM | 0.0556 mL | 0.2781 mL | 0.5562 mL | 1.3904 mL | |
50 mM | 0.0445 mL | 0.2225 mL | 0.4449 mL | 1.1123 mL | |
60 mM | 0.0371 mL | 0.1854 mL | 0.3708 mL | 0.9270 mL | |
80 mM | 0.0278 mL | 0.1390 mL | 0.2781 mL | 0.6952 mL | |
100 mM | 0.0222 mL | 0.1112 mL | 0.2225 mL | 0.5562 mL |