iFSP1 [150651-39-1]
Référence T11631-10mg
Conditionnement : 10mg
Marque : TargetMol
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iFSP1
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iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1.
Cas No. 150651-39-1
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.74%
Appearance:Solid
Color:Yellow
COA HPLC HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1. |
| Targets & IC50 | FSP1:103 nM (EC50) |
| In vitro | iFSP1 (0.001-1 μM; 24 hours) is less effective than genetic deletion of FSP1, and its treatment in the FSP1-knockout background does not enhance RSL3-induced ferroptosis. iFSP1 (3 μM; 24 hours) causes significant toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines. AIFM2, now renamed ferroptosis suppressor protein 1 (FSP1), is identified as a previously unrecognized anti-ferroptotic gene. iFSP1 (0.001-1 μM; 24 hours) inhibits the growth of Gpx4-knockout cells in a dose-dependent manner but does not affect wild type cells. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4-knockout cells from iFSP1-induced ferroptosis. |
| Molecular Weight | 323.35 |
| Formula | C20H13N5 |
| Cas No. | 150651-39-1 |
| Smiles | Cc1ccc(cc1)-c1c(C#N)c(N)n2c3ccccc3nc2c1C#N |
| Relative Density. | 1.31 g/cm3 (Predicted) |
| Storage | The compound is unstable in solution. Please use soon Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (77.32 mM), Sonication is recommended.The compound is unstable in solution, please use soon.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||