Integrin beta3 (Phospho-Tyr785) Antibody
Référence MBS858837-0,1mL-AF488
Conditionnement : 0.1mL(AF488)
Marque : MyBiosource
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Western blot analysis of extracts from 293 cells treated with Insulin (0.01U/ml, 15mins), using, using Integrin beta3 (phospho-Tyr785) antibody (Line 1 and 2).
Integrin Beta3 (ITB3) Antibody
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS858837MBS858837 is an antibody targeting ITB3. Also known as Integrin beta3 (Phospho-Tyr785) Antibody. Reactive in Human, Mouse. More details
Product Overview
Online Datasheet in PDFProduct Name
Integrin beta3 (ITB3), Antibody
Full Product Name
Integrin beta3 (Phospho-Tyr785) Antibody
Product Gene Name
anti-ITB3 antibody
Product Synonym Names
CD61 antigen; GP3A; GPIIIa; Integrin beta-3 precursor; Platelet membrane glycoprotein IIIa; integrin beta-3
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificity
Integrin beta3 (phospho-Tyr785) antibody detects endogenous levels of Integrin beta3 only when phosphorylated at tyrosine 785.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
86,694 Da
OMIM
173470
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human Integrin beta3 around the phosphorylation site of tyrosine 785 (I-T-YP-R-G).
All Sites
Human: Thr785
Mouse: Thr784
Mouse: Thr784
Product Categories/Family for anti-ITB3 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ITB3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ITB3 antibody
WB: 1:500-1:1000
ELISA: 1:10000
ELISA: 1:10000
Product References and Citations for anti-ITB3 antibody
Anirban Datta, J. Biol. Chem., Feb 2002; 277: 3943-3949. Alison L. Jenkins, J. Biol. Chem., May 1998; 273: 13878. Scott D. Blystone, J. Biol. Chem., Nov 1997; 272: 28757. Rita I. Kirk, J. Biol. Chem., Sep 2000; 275: 30901.
Other Notes
Small volumes of anti-ITB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for ITB3. It may not necessarily be applicable to this product.
NCBI Official Full Name
integrin beta-3
NCBI Official Synonym Full Names
integrin subunit beta 3
NCBI Official Symbol
ITGB3
NCBI Official Synonym Symbols
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
UniProt Protein Name
Integrin beta-3
UniProt Synonym Protein Names
Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61
UniProt Gene Name
ITGB3
UniProt Synonym Gene Names
GP3A; GPIIIa
NCBI Protein Information
integrin beta-3
NCBI Summary for ITB3
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for ITB3
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887).
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-ITB3 antibody
| Reference Product | PubMed Publications |
|---|---|
| ITGA2B antibody | >46 publications with ITB3 and ITGA2B |
| ITGAV antibody | >13 publications with ITB3 and ITGAV |
| ITGA5 antibody | >6 publications with ITB3 and ITGA5 |
| PECAM1 antibody | >4 publications with ITB3 and PECAM1 |
| THBS1 antibody | >3 publications with ITB3 and THBS1 |
| SRC antibody | >3 publications with ITB3 and SRC |
| PTK2 antibody | >3 publications with ITB3 and PTK2 |
| FN1 antibody | >2 publications with ITB3 and FN1 |
| FGG antibody | >2 publications with ITB3 and FGG |
| FGA antibody | >2 publications with ITB3 and FGA |
Pathways associated with anti-ITB3 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Arf6 Signaling Events Pathway antibodies | Arf6 Signaling Events Pathway Diagram |
| Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies | Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram |
| Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies | Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram |
| Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies | Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram |
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| Cell Surface Interactions At The Vascular Wall Pathway antibodies | Cell Surface Interactions At The Vascular Wall Pathway Diagram |
| Developmental Biology Pathway antibodies | Developmental Biology Pathway Diagram |
| Dilated Cardiomyopathy Pathway antibodies | Dilated Cardiomyopathy Pathway Diagram |
| Dilated Cardiomyopathy Pathway antibodies | Dilated Cardiomyopathy Pathway Diagram |
| ECM-receptor Interaction Pathway antibodies | ECM-receptor Interaction Pathway Diagram |
Diseases associated with anti-ITB3 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Cardiovascular Diseases Antibodies | >52 publications with ITB3 and Cardiovascular Diseases |
| Neoplasms Antibodies | >38 publications with ITB3 and Neoplasms |
| Thrombocytopenia Antibodies | >25 publications with ITB3 and Thrombocytopenia |
| Thrombasthenia Antibodies | >25 publications with ITB3 and Thrombasthenia |
| Thrombosis Antibodies | >18 publications with ITB3 and Thrombosis |
| Myocardial Infarction Antibodies | >16 publications with ITB3 and Myocardial Infarction |
| Breast Neoplasms Antibodies | >12 publications with ITB3 and Breast Neoplasms |
| Stroke Antibodies | >10 publications with ITB3 and Stroke |
| Child Development Disorders, Pervasive Antibodies | >9 publications with ITB3 and Child Development Disorders, Pervasive |
| Autistic Disorder Antibodies | >9 publications with ITB3 and Autistic Disorder |
Organs/Tissues associated with anti-ITB3 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >122 publications with ITB3 and Blood |
| Vascular Antibodies | >25 publications with ITB3 and Vascular |
| Bone Antibodies | >15 publications with ITB3 and Bone |
| Uterus Antibodies | >8 publications with ITB3 and Uterus |
| Placenta Antibodies | >8 publications with ITB3 and Placenta |
| Lung Antibodies | >6 publications with ITB3 and Lung |
| Kidney Antibodies | >6 publications with ITB3 and Kidney |
| Lymph Node Antibodies | >5 publications with ITB3 and Lymph Node |
| Muscle Antibodies | >4 publications with ITB3 and Muscle |
| Embryonic Tissue Antibodies | >4 publications with ITB3 and Embryonic Tissue |