Involucrin (APC)
Référence MBS6268930-5x0,1mL
Conditionnement : 5x0.1mL
Marque : MyBiosource
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Involucrin (IVL) Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6268930MBS6268930 is an antibody targeting IVL. Also known as Involucrin (APC). Reactive in Canine, Human, Monkey, Porcine. Host: Mouse. More details
Product Overview
Online Datasheet in PDFProduct Name
Involucrin (IVL), Monoclonal Antibody
Full Product Name
Involucrin (APC)
Product Gene Name
anti-IVL antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
SY5
Host
Mouse
Species Reactivity
Canine, Human, Monkey, Porcine
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography
Specificity
Recognizes human Involucrin. Species Crossreactivity: Porcine, monkey, canine, gorilla.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
68,479 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (152881039..152884362). Location: 1q21
OMIM
147360
Immunogen
Purified involucrin from human keratinocytes.
Conjugate
APC
Product Categories/Family for anti-IVL antibody
Antibodies; Extracellular Matrix Proteins
Applications Tested/Suitable for anti-IVL antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Product References and Citations for anti-IVL antibody
1. Hudson, D.L. et al. (1992) Characterization of eight monoclonal antibodies to involucrin. Hybridoma. 3: 367379. 2. Ishida-Yamamoto, A. et al. (1997) Involucrin and SPRR Are Synthesized Sequentially in Differentiating Cultured Epidermal Cells. J Invest Dermatol. 108: 12-6. 3. Caldelari, R. et al. (2000) Long-term culture of murine epidermal keratinocytes. J Invest Dermatol. 114: 1064-5. 4. Ishida-Yamamoto, A. et al. (1996) Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis. J Histochem Cytochem. 44: 167-75. 5. Janes,S.M. and Watt, F.M. (2004) Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol. 166: 419-31. 6. Michael, M. et al. (2014) BPAG1-e restricts keratinocyte migration through control of adhesion stability. J Invest Dermatol. 134: 773-82. 7. Hanada, T. et al. (2014) Keratinization induced by air exposure in the reconstructed human epidermal model: An in vitro model of a cultured epithelial autograft J Biosci Bioeng. pii: S1389-1723(14)00071-1.
Other Notes
Small volumes of anti-IVL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for IVL. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
involucrin
NCBI Official Synonym Full Names
involucrin
NCBI Official Symbol
IVL
UniProt Protein Name
Involucrin
Protein Family
Involucrin
UniProt Gene Name
IVL
UniProt Entry Name
INVO_HUMAN
NCBI Protein Information
involucrin
NCBI Summary for IVL
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
UniProt Comments for IVL
IVL: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Belongs to the involucrin family.
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: cytoplasm; cornified envelope
Molecular Function: protein binding, bridging; structural molecule activity
Biological Process: keratinocyte differentiation; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; keratinization; peptide cross-linking; response to UV-B
Show more Chromosomal Location of Human Ortholog: 1q21
Cellular Component: cytoplasm; cornified envelope
Molecular Function: protein binding, bridging; structural molecule activity
Biological Process: keratinocyte differentiation; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; keratinization; peptide cross-linking; response to UV-B
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-IVL antibody
| Reference Product | PubMed Publications |
|---|---|
| SPRR3 antibody | >2 publications with IVL and SPRR3 |
Pathways associated with anti-IVL antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies | Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram |
Diseases associated with anti-IVL antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >182 publications with IVL and Neoplasms |
| Immune System Diseases Antibodies | >148 publications with IVL and Immune System Diseases |
| Skin Neoplasms Antibodies | >42 publications with IVL and Skin Neoplasms |
| Brain Diseases Antibodies | >37 publications with IVL and Brain Diseases |
| Lung Neoplasms Antibodies | >26 publications with IVL and Lung Neoplasms |
| Drug Toxicity Antibodies | >17 publications with IVL and Drug Toxicity |
| Heart Diseases Antibodies | >15 publications with IVL and Heart Diseases |
| Liver Neoplasms Antibodies | >15 publications with IVL and Liver Neoplasms |
| Neoplasm Invasiveness Antibodies | >14 publications with IVL and Neoplasm Invasiveness |
| Anemia Antibodies | >12 publications with IVL and Anemia |
Organs/Tissues associated with anti-IVL antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Skin Antibodies | >70 publications with IVL and Skin |
| Brain Antibodies | >55 publications with IVL and Brain |
| Muscle Antibodies | >38 publications with IVL and Muscle |
| Lung Antibodies | >33 publications with IVL and Lung |
| Esophagus Antibodies | >3 publications with IVL and Esophagus |
| Prostate Antibodies | >3 publications with IVL and Prostate |
| Larynx Antibodies | >2 publications with IVL and Larynx |
| Mouth Antibodies | >2 publications with IVL and Mouth |
| Mammary Gland Antibodies | >1 publications with IVL and Mammary Gland |
| Bladder Antibodies | >1 publications with IVL and Bladder |