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> KIR2DL4 Protein, Human, Recombinant (His)

KIR2DL4 Protein, Human, Recombinant (His)

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KIR2DL4 Protein, Human, Recombinant (His)

(Synonyms: MHC Class I NK Cell Receptor KIR103AS, KIR2DL4, KIR-103AS, KIR103AS, Killer Cell Inhibitory Receptor 103AS, Killer Cell Immunoglobulin-Like Receptor 2DL4, G9P, CD158D, CD158 Antigen-Like Family Member D) Copy Product Info

Synonyms: MHC Class I NK Cell Receptor KIR103AS, KIR2DL4, KIR-103AS, KIR103AS, Killer Cell Inhibitory Receptor 103AS, Killer Cell Immunoglobulin-Like Receptor 2DL4, G9P, CD158D, CD158 Antigen-Like Family Member D

Catalog No. TMPJ-00604 Copy Product Info
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
Other Forms of KIR2DL4 Protein, Human, Recombinant (His):
KIR2DL4 Protein, Human, Recombinant (hFc)
KIR2DL4 Protein, Human, Recombinant
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
Species
Human
Expression System
HEK293 Cells
TagC-6xHis
Accession NumberADY38409.1
Amino AcidTrp22-His242
ConstructionTrp22-His242
Protein Purity
Greater than 80% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsMHC Class I NK Cell Receptor KIR103AS, KIR2DL4, KIR-103AS, KIR103AS, Killer Cell Inhibitory Receptor 103AS, Killer Cell Immunoglobulin-Like Receptor 2DL4, G9P, CD158D, CD158 Antigen-Like Family Member D
Research Background
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
Chemical Properties
Molecular Weight30-40 KDa (reducing condition)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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