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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

KITLG Blocking Peptide (C-term)

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Conditionnement : 500ug

Téléphone : +1 850 650 7790

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Téléphone : +1 850 650 7790

Synthetic peptide

Primary Accession	P21583

Gene ID	4254
Other Names	Kit ligand, Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand, Soluble KIT ligand, sKITLG, KITLG, MGF, SCF
Target/Specificity	The synthetic peptide sequence is selected from aa 201-214 of HUMAN KITLG
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Storage	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Precautions	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

For Research Use Only. Not For Use In Diagnostic Procedures.

Name	KITLG (HGNC:6343)
Synonyms	MGF, SCF
Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Cellular Location	[Isoform 1]: Cell membrane; Single-pass type I membrane protein [Soluble KIT ligand]: Secreted.

Research Areas