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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

L-Citrulline [372-75-8]

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Référence NB-64-29049-1g

Conditionnement : 1g

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L-Citrulline

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Synonyms:

Catalog No. T4813 Copy Product Info

Purity: 99.93%

L-Citrulline, an amino acid, is derived from ornithine during the catabolism of proline, glutamate, or glutamine, and also from L-arginine via the arginine-citrulline pathway.

Cas No. 372-75-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.93%

Appearance:Solid

Color:White

Product Introduction

L-Citrulline AI Summary

L-Citrulline exhibits diverse bioactivities across various assays. It has been observed that L-Citrulline shows no inhibition of the human aquaporin 4 M23 isoform in Xenopus laevis oocytes at a 20 μM concentration. Additionally, it shows activity against nitrogen-starved wild type sigma1278b Gap1, with a Km value of 37000.0 nM, and has a dissociation constant (Kd) of 68000.0 nM. The compound significantly inhibits sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells by 135.09% and 119.67% respectively at a concentration of 10 μM. In terms of its antiviral properties, L-Citrulline exhibits activity against SARS-CoV-2. It inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells at a concentration of 10 μM after 48 hours, showing a potential inhibitory effect on virus-induced cytotoxicity. Further, it shows moderate antiviral activity against the SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, with a hit score of 0.1542. The compound also inhibits the SARS-CoV-2 3CL-Pro protease at a 20 μM concentration, demonstrating inhibition percentages of 30.93% and 17.14%. Moreover, it displays antiviral activity against SARS-CoV-2 in VERO-6 cells at a 10 μM concentration after 48 hours of exposure, with observed inhibition ranging from -0.07% to 0.26%. Despite these activities, L-Citrulline has not shown significant bioactivity towards other tested targets, with AC50 values greater than 30000.0 nM in all assays evaluated, indicating limited interaction with those specific biological pathways or receptors..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Citrulline, an amino acid, is derived from ornithine during the catabolism of proline, glutamate, or glutamine, and also from L-arginine via the arginine-citrulline pathway.

Chemical Properties

Molecular Weight	175.19
Formula	C₆H₁₃N₃O₃
Cas No.	372-75-8
Smiles	C(CCNC(N)=O)[C@@H](C(O)=O)N
Relative Density.	1.289 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (570.81 mM), Sonication and heating are recommended.

DMSO: Insoluble

5% DMSO＋40% PEG300＋5% Tween-80＋50% ddH2O: 0.62 mg/mL (3.54 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
5 mM	1.1416 mL	5.7081 mL	11.4162 mL	57.0809 mL
10 mM	0.5708 mL	2.8540 mL	5.7081 mL	28.5404 mL
20 mM	0.2854 mL	1.4270 mL	2.8540 mL	14.2702 mL
50 mM	0.1142 mL	0.5708 mL	1.1416 mL	5.7081 mL
100 mM	0.0571 mL	0.2854 mL	0.5708 mL	2.8540 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

L-CitrullineLCitrullineL CitrullineInhibitorinhibitEndogenousMetaboliteEndogenous Metabolite

Related Tags: L-Citrulline chemical structure | L-Citrulline formula | L-Citrulline molecular weight