L-Histidine [71-00-1]
Référence T2A2532-500mg
Conditionnement : 500mg
Marque : TargetMol
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L-Histidine
(Synonyms: L-(-)-Histidine, histidine, Glyoxaline-5-alanine) Copy Product Info
L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect nerve cells and is metabolized to the neurotransmitter histamine. Histamines play many roles in immunity, gastric secretion, and sexual functions. L-Histidine is also required for blood cell manufacture and protects tissues against damage caused by radiation and heavy metals.
Cas No. 71-00-1
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.92%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Introduction
L-Histidine AI Summary
L-Histidine exhibits versatile bioactivity with notable activation of various carbonic anhydrase (CA) enzymes. It shows potent activation of human CA1 (KA = 0.03 µM), moderate activation of human CA2 (KA = 10.9 µM), and different degrees of activation for other CAs such as CA4, CA5A, CA5B, CA6, CA9, CA12, CA13, and CA14, with KA values ranging from 0.13 µM to 135.0 µM. Additionally, it demonstrates bioactivity in other biological processes, including reducing blood glucose levels in KKAy mice at a dose of 500 mg/kg over 4 days (MISS T/C = 0.8), and antioxidant activity by inhibiting the formation of hydroxyl radicals and reactive oxygen species (EC50 values of 100,000 nM and 6,000 nM, respectively). The compound also shows binding affinity (Kd = -7.31) to human histidine-binding proteins, inhibition of LAT1 with an IC50 of 200,000 nM, and pKa value of 6.2. These diverse bioactivities highlight its potential in modulating a variety of physiological processes and therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect nerve cells and is metabolized to the neurotransmitter histamine. Histamines play many roles in immunity, gastric secretion, and sexual functions. L-Histidine is also required for blood cell manufacture and protects tissues against damage caused by radiation and heavy metals. |
| Synonyms | L-(-)-Histidine, histidine, Glyoxaline-5-alanine |
| Molecular Weight | 155.16 |
| Formula | C6H9N3O2 |
| Cas No. | 71-00-1 |
| Smiles | C([C@@H](C(O)=O)N)C1=CN=CN1 |
| Relative Density. | 1.423 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 29.70 mg/mL (191.42 mM), Sonication is recommended.  DMSO: Insoluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||