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Lactic acid sodium (60% w/w in water) [72-17-3]

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Référence NB-64-143585-50mg

Conditionnement : 50mg

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Lactic acid sodium (60% w/w in water)

(Synonyms: E-270 sodium (60% w/w in water)) Copy Product Info

Synonyms: E-270 sodium (60% w/w in water)

Catalog No. T212648 Copy Product Info

Purity: 99.86%

Lactic acid sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and also an epigenetic regulator that induces lactylation of lysine residues. Lactic acid sodium, as the end product of glycolysis, bridges the gap between glycolysis and oxidative phosphorylation. In tumor metabolism, Lactic acid sodium exerts the immunoprotective effect of lactate, contributing to antitumor immunity. In addition, Lactic acid sodium also possesses antibacterial activity and can be used as a food preservative.

Cas No. 72-17-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.86%

Appearance:Liquid

Color:Transparent

Product Information

Bioactivity

Description	Lactic acid sodium (60% w/w in water) is an activator of hydroxycarboxylic acid receptor 1 (HCAR1) and also an epigenetic regulator that induces lactylation of lysine residues. Lactic acid sodium, as the end product of glycolysis, bridges the gap between glycolysis and oxidative phosphorylation. In tumor metabolism, Lactic acid sodium exerts the immunoprotective effect of lactate, contributing to antitumor immunity. In addition, Lactic acid sodium also possesses antibacterial activity and can be used as a food preservative.
In vitro	Method: Lactic acid sodium (60% w/w in water) (the study used reagent-grade sodium lactate solution containing approximately 59%–61% w/w lactate and predominantly the L-isomer) was added to neutral-pH culture media containing food-associated bacteria. Result: Approximately 5% sodium lactate prolonged the lag phase and reduced growth yield in several lactic-acid bacteria, Staphylococcus aureus and Salmonella Typhimurium; activity could not be explained by pH alone.^[1]
In vivo	Lactic acid (1.6 g/kg; pH 7.4; subcutaneous injection; once daily; from day 8 to 30) with sodium (60% w/w in water) exhibits CD8+ T cell-dependent tumor growth inhibition in the MC38 colon cancer model. Note: Adjust the working solution's pH to approximately 7.4 before administration in animals.
Synonyms	E-270 sodium (60% w/w in water)

Chemical Properties

Molecular Weight	112.06
Formula	C₃H₅NaO₃
Cas No.	72-17-3
Smiles	O=C(C(C)O)[O-].[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 93.34 mg/mL (832.95 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	8.9238 mL	44.6190 mL	89.2379 mL	446.1895 mL
5 mM	1.7848 mL	8.9238 mL	17.8476 mL	89.2379 mL
10 mM	0.8924 mL	4.4619 mL	8.9238 mL	44.6190 mL
20 mM	0.4462 mL	2.2309 mL	4.4619 mL	22.3095 mL
50 mM	0.1785 mL	0.8924 mL	1.7848 mL	8.9238 mL
100 mM	0.0892 mL	0.4462 mL	0.8924 mL	4.4619 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Related Tags: Lactic acid sodium (60% w/w in water) chemical structure | Lactic acid sodium (60% w/w in water) in vivo | Lactic acid sodium (60% w/w in water) in vitro | Lactic acid sodium (60% w/w in water) formula | Lactic acid sodium (60% w/w in water) molecular weight