LBH589 (Panobinostat)
Référence MBS385848-200mg
Conditionnement : 200mg
Marque : MyBiosource
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LBH589 (Panobinostat) Inhibitor
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS385848LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM. More details
Product Overview
Online Datasheet in PDFProduct Name
LBH589 (Panobinostat), Inhibitor
Full Product Name
LBH589 (Panobinostat)
Product Synonym Names
NVP-LBH589; LBH-589
Form/Format
Powder
Purity/Purification
>98%
Concentration
0.1 mM: 28.62 mL (1 mg); 143.1 mL (5 mg); 286.2mL (10 mg)
0.5 mM: 5.72 mL (1 mg); 28.62 mL (5 mg); 57.24 mL (10 mg)
1 mM: 2.86 mL (1 mg); 14.31 mL (5 mg); 28.62 mL (10 mg)
5 mM: 0.57 mL (1 mg); 2.86 mL (5 mg); 5.72 mL (10 mg) (lot specific)
0.5 mM: 5.72 mL (1 mg); 28.62 mL (5 mg); 57.24 mL (10 mg)
1 mM: 2.86 mL (1 mg); 14.31 mL (5 mg); 28.62 mL (10 mg)
5 mM: 0.57 mL (1 mg); 2.86 mL (5 mg); 5.72 mL (10 mg) (lot specific)
Preparation and Storage
at -20 degree C 3 years Powder
Molecular Weight
349.4
CAS Number
404950-80-7
Formula
C21H23N3O2
SMILES
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
Actions
Inhibitor
In Vivo Solvent
Add solvents to the product individually and in order: 2% DMSO+48% PEG 300+2% Tween 80+ddH2O
Solubility (DMSO)
69 mg/mL (197.46 mM)
Solubility (Ethanol)
<1 mg/mL (<1 mM)
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Product References and Citations for LBH589 (Panobinostat), inhibitor
Justin Kale, .et al. Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance, EMBO Rep, 2018, Sep; 19(9): e45235 PMID: 29987135
Other Notes
Small volumes of LBH589 (Panobinostat), inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for LBH589 (Panobinostat) purchase
MBS385848 is an inhibitor targeting LBH589 (Panobinostat).