Luliconazole [187164-19-8]
Référence T2411-1g
Conditionnement : 1g
Marque : TargetMol
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Luliconazole
(Synonyms: NND 502) Copy Product Info
Luliconazole (NND 502) is an Azole Antifungal. The mechanism of action of luliconazole is as a Cytochrome P450 2C19 Inhibitor.
Cas No. 187164-19-8
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.83%
Appearance:Solid
Color:White
COA LCMS HNMR
Product Introduction
Luliconazole AI Summary
Luliconazole exhibits a range of bioactivities, primarily serving as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies between 5956.9 nM and 33498.3 nM, in both the absence and presence of camptothecin (CPT). It also demonstrates antiviral properties, effectively blocking the entry of the Ebola virus with AC50 values between 39.81 µM to 39810.7 nM. In terms of SARS-CoV-2 inhibition, Luliconazole shows varying degrees of effectiveness; it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with a 14.33% inhibition rate at 10 µM concentration after 48 hours, and in VERO-6 cells, it shows a 0.62% inhibition rate under similar conditions. Additionally, the compound presented a hit score of 0.09705 for the inhibition of SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells and demonstrated a 7.07% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. It also showcases inhibitory activity against human HDAC6, with inhibition percentages of 17.84% and 1.21% in enzymatic assays using commercial and custom peptide substrates, respectively..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Luliconazole (NND 502) is an Azole Antifungal. The mechanism of action of luliconazole is as a Cytochrome P450 2C19 Inhibitor. |
| In vitro | Luliconazole inhibits the growth of all filamentous fungi (except Saccharomyces cerevisiae) (MIC,≦0.004-0.125 μg/ml), Candida albicans (MIC range: 0.031-0.13 mg/ml), Trichophyton rubrum (MIC,≦0.00012-0.002 mg/ml). |
| In vivo | Luliconazole inhibits the growth of all filamentous fungi (except Saccharomyces cerevisiae) (MIC,≦0.004-0.125 μg/ml), Candida albicans (MIC range: 0.031-0.13 mg/ml), Trichophyton rubrum (MIC,≦0.00012-0.002 mg/ml). |
| Synonyms | NND 502 |
| Molecular Weight | 354.28 |
| Formula | C14H9Cl2N3S2 |
| Cas No. | 187164-19-8 |
| Smiles | Clc1ccc([C@@H]2CS\C(S2)=C(\C#N)n2ccnc2)c(Cl)c1 |
| Relative Density. | 1.52 g/cm3 (Predicted) |
| Storage | Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 166.67 mg/mL (470.45 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 5 mg/mL (14.11 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (28.23 mM), Solution. 10% DMSO+90% Saline: < 10 mg/mL (28.23 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||