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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

MBL2 Blocking Peptide

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Conditionnement : 500ug

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Synthetic peptide

Primary Accession	P11226

Gene ID	4153
Other Names	Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin, MBL2, COLEC1, MBL
Target/Specificity	The synthetic peptide sequence is selected from aa 210-221 of HUMAN MBL2
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Storage	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Precautions	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

For Research Use Only. Not For Use In Diagnostic Procedures.

Name	MBL2 (HGNC:6922)
Function	Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:14515269, PubMed:22966085, PubMed:7634089, PubMed:9087411). Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:22966085, PubMed:2573758, PubMed:6643429, PubMed:8082295, PubMed:9087411). Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342). May bind DNA (PubMed:15145932).
Cellular Location	Secreted. Cell surface. Note=Specifically binds mannose moiety of carbohydrates on the surface of pathogens.
Tissue Location	Plasma protein produced mainly in the liver.

Research Areas