Melanin Concentrating Hormone (MCH) (human, mouse, rat) (Biotin)
Référence MBS657944-5x1mg
Conditionnement : 5x1mg
Marque : MyBiosource
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Melanin Concentrating Hormone (MCH) (Human, Mouse, Rat) (Biotin) Peptide – Synthetic Peptide, ~90%. Purified by HPLC. Purity
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS657944MBS657944 is a peptide targeting PMCH. Also known as Melanin Concentrating Hormone (MCH) (human, mouse, rat) (Biotin). Reactive in Human, Mouse, Rat. Host: Synthetic peptide. More details
Product Overview
Product Name
Melanin Concentrating Hormone (PMCH), Peptide
Full Product Name
Melanin Concentrating Hormone (MCH) (human, mouse, rat) (Biotin)
Product Gene Name
PMCH peptide
Host
Synthetic peptide
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a lyophilized powder.
Purity/Purification
Highly Purified
~90%. Purified by HPLC.
~90%. Purified by HPLC.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
2615.20
Chromosome Location
Chromosome: 12; NC_000012.11 (102590237..102591614, complement). Location: 12q23.2
OMIM
176795
Sequence (linear)
Biotin-Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val
Molecular Formula
C115H176N32O28S5
Product Categories/Family for PMCH peptide
Other Notes
Small volumes of PMCH peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for PMCH. It may not necessarily be applicable to this product.
NCBI Official Full Name
melanin concentrating hormone
NCBI Official Synonym Full Names
pro-melanin-concentrating hormone
NCBI Official Symbol
PMCH
NCBI Official Synonym Symbols
MCH
UniProt Protein Name
Pro-MCH
Protein Family
Pro-MCH
UniProt Gene Name
PMCH
UniProt Synonym Gene Names
MCH; NGE; Neuropeptide G-E; NEI; Neuropeptide E-I; MCH
UniProt Entry Name
MCH_HUMAN
NCBI Protein Information
pro-MCH
NCBI Summary for PMCH
The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary by Nahon et al., 1992 [PubMed 1572663]).[supplied by OMIM, Jan 2011]
Show more UniProt Comments for PMCH
Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.
Subcellular location: Secreted.
Tissue specificity: Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. Ref.6
Post-translational modification: Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.
Sequence similarities: Belongs to the melanin-concentrating hormone family.
Show more Subcellular location: Secreted.
Tissue specificity: Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. Ref.6
Post-translational modification: Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.
Sequence similarities: Belongs to the melanin-concentrating hormone family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with PMCH peptide
| Reference Product | PubMed Publications |
|---|---|
| HCRT peptide | >2 publications with PMCH and HCRT |
| POMC peptide | >1 publications with PMCH and POMC |
| PENK peptide | >1 publications with PMCH and PENK |
| NPY peptide | >1 publications with PMCH and NPY |
Pathways associated with PMCH peptide
| Products by Pathway | Pathway Diagram |
|---|---|
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| G Alpha (q) Signalling Events Pathway antibodies | G Alpha (q) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies | Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram |
| Peptide Ligand-binding Receptors Pathway antibodies | Peptide Ligand-binding Receptors Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signaling By GPCR Pathway antibodies | Signaling By GPCR Pathway Diagram |
Diseases associated with PMCH peptide
| Disease Name | Pubmed Publications |
|---|---|
| Obesity Antibodies | >8 publications with PMCH and Obesity |
| Weight Gain Antibodies | >3 publications with PMCH and Weight Gain |
| Nervous System Diseases Antibodies | >2 publications with PMCH and Nervous System Diseases |
| Weight Loss Antibodies | >2 publications with PMCH and Weight Loss |
| Growth Disorders Antibodies | >1 publications with PMCH and Growth Disorders |
| Hyperglycemia Antibodies | >1 publications with PMCH and Hyperglycemia |
| Birth Weight Antibodies | >1 publications with PMCH and Birth Weight |
| Lymphoma Antibodies | >1 publications with PMCH and Lymphoma |
| Cardiovascular Diseases Antibodies | >1 publications with PMCH and Cardiovascular Diseases |
| Inflammation Antibodies | >1 publications with PMCH and Inflammation |
Organs/Tissues associated with PMCH peptide
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >13 publications with PMCH and Brain |
| Connective Tissue Antibodies | >1 publications with PMCH and Connective Tissue |
| Testis Antibodies | >1 publications with PMCH and Testis |
| Kidney Antibodies | >1 publications with PMCH and Kidney |
| Placenta Antibodies | >1 publications with PMCH and Placenta |