Melanocortin Receptor 2, Mouse (MC2-R, ACTH-R, a-MSH Receptor, MSH Receptor) (Control Peptide)

A 17 aa peptide from the 4th cytoplasmic domain of the murine MC2-R.

Melanocortins are regulatory peptides formed by post-translational processing of pro-opiomelanocortin. Melanocortin peptides have been suggested to perform a variety of physiological roles ranging from control of behavior, memory, neurotrophic properties, antipyretic and modulation of immune system, etc. Their binding sites have been found distributed in tissues ranging from lachrymal and submandibular glands, pancreas, adipose tissue, bladder, duodenum, spleen, brain, gonadal tissues and malignant melanoma tumors. Five melanocortin receptors have been characterized to date. These include melanocyte-stimulating hormone receptor (MSH or MC1-R), corticoaderenal-specific ACTH receptor (MC2-R), melacortin-3 (MC3-R), melanocortin-4 (MC4-R) and melanocortin-5 receptor (MC5-R). MC3-R and MC4-R are distributed in brain whereas MC5-R has a broad distribution.

Mouse Melanocortin receptor (MC2-R or ACTH-R) is a 296 amino acid transmembrane protein belonging to the family of G-Protein coupled receptors. It is a receptor for ACTH. It is found in melanocyte and corticoadrenal tissues. Defects in MC2-R are the cause of familial glucocorticoid deficiency. An autosomal recessive disorder due to congenital insensitivity or resistance to ACTH and characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.