Miconazole [22916-47-8]
Référence NB-64-00509-500mg
Conditionnement : 500mg
Marque : Neo Biotech
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Miconazole (Synonyms: R18134)
Catalog No. T0344 Copy Product Info
Purity: 99.89%
Miconazole (R18134) is an imidazole antifungal agent used both topically and via intravenous infusion.
Miconazole
Copy Product InfoSynonyms R18134
Miconazole (R18134) is an imidazole antifungal agent used both topically and via intravenous infusion.
Cas No. 22916-47-8
Product Introduction
Miconazole AI Summary
Miconazole exhibits potent antifungal activity against a variety of fungal pathogens, particularly against Candida species and dermatophytes. It shows high efficacy with low minimum inhibitory concentrations (MIC) ranging from 0.156 to 25.0 ug/mL, indicating strong inhibitory effects against Candida albicans, Aspergillus fumigatus, Trichophyton mentagrophytes, and others. Additionally, Miconazole demonstrates fungicidal activity with MIC values often below 0.78 ug/mL for some dermatophytes like Microsporum canis and Trichophyton asteroides. In in vivo studies, Miconazole significantly inhibits fungal infections in animal models such as guinea pigs and hamsters, reducing lesion scores and fungal culture positivity. It enhances the activity of enzymes like styrene oxide hydrolase and epoxide hydrolase, indicated by specific enhancement metrics and partition coefficients like LogP (5.84). The compound is also an effective inhibitor of Cytochrome P450 enzymes, particularly CYP51, and shows inhibitory activity against Cytochrome P450 3A4 with relevant IC50 values, contributing to its wide spectrum of bioactivity. Moreover, Miconazole exhibits inhibitory effects on other enzymes and proteins, including beta-lactamase, malate dehydrogenase, and Tdo2. The compound's bioactivity spectrum extends to showing cytotoxicity in human cell lines and specific antimicrobial activity against various bacterial strains, although it demonstrates moderate to low antibacterial efficacy. Overall, Miconazole is a promising antifungal agent with potential applications in treating diverse fungal infections..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Miconazole (R18134) is an imidazole antifungal agent used both topically and via intravenous infusion. |
| Synonyms | R18134 |
| Molecular Weight | 416.13 |
| Formula | C18H14Cl4N2O |
| Cas No. | 22916-47-8 |
| Smiles | C(CN1C=CN=C1)(OCC2=C(Cl)C=C(Cl)C=C2)C3=C(Cl)C=C(Cl)C=C3 |
| Relative Density. | 1.4g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (600.77 mM), Sonication is recommended.  Ethanol: 77 mg/mL (185.04 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.81 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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