MXD4 Antibody
Référence MBS8583931-0,1mL-HRP
Conditionnement : 0.1mL(HRP)
Marque : MyBiosource
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MXD4 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8583931MBS8583931 is an antibody targeting MXD4. Also known as MXD4 Antibody. Reactive in Human, Mouse, Rat, Bovine, Sheep. Host: Rabbit. Rabbit polyclonal antibody to MXD4 More details
Product Overview
Online Datasheet in PDFProduct Name
MXD4, Polyclonal Antibody
Full Product Name
MXD4 Antibody
Product Gene Name
anti-MXD4 antibody
Product Synonym Names
BHLHC12; MAD4; Max dimerization protein 4; Max dimerizer 4; Class C basic helix-loop-helix protein 12; bHLHc12; Max-associated protein 4; Max-interacting transcriptional repressor MAD4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Sheep
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of MXD4 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
23,528 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (2249160..2263739, complement). Location: 4p16.3
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MXD4. The exact sequence is proprietary.
Product Categories/Family for anti-MXD4 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MXD4 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MXD4 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-MXD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for MXD4. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
max dimerization protein 4
NCBI Official Synonym Full Names
MAX dimerization protein 4
NCBI Official Symbol
MXD4
NCBI Official Synonym Symbols
MAD4; MST149; MSTP149; bHLHc12
UniProt Protein Name
Max dimerization protein 4
UniProt Synonym Protein Names
Class C basic helix-loop-helix protein 12; bHLHc12; Max-associated protein 4; Max-interacting transcriptional repressor MAD4
Protein Family
Max dimerization protein
UniProt Gene Name
MXD4
UniProt Synonym Gene Names
BHLHC12; MAD4; Max dimerizer 4; bHLHc12
UniProt Entry Name
MAD4_HUMAN
NCBI Protein Information
max dimerization protein 4; Mad4 homolog; max dimerizer 4; max-associated protein 4; class C basic helix-loop-helix protein 12; max-interacting transcriptional repressor MAD4
NCBI Summary for MXD4
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for MXD4
Mad4: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription corepressor activity
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter
Show more Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription corepressor activity
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter
Research Articles on MXD4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-MXD4 antibody
| Reference Product | PubMed Publications |
|---|---|
| MAX antibody | >5 publications with MXD4 and MAX |
| TCP10L antibody | >1 publications with MXD4 and TCP10L |
Pathways associated with anti-MXD4 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies | Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram |
Organs/Tissues associated with anti-MXD4 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >2 publications with MXD4 and Blood |
| Liver Antibodies | >2 publications with MXD4 and Liver |
| Embryonic Tissue Antibodies | >2 publications with MXD4 and Embryonic Tissue |
| Parathyroid Antibodies | >1 publications with MXD4 and Parathyroid |
| Nerve Antibodies | >1 publications with MXD4 and Nerve |
| Ovary Antibodies | >1 publications with MXD4 and Ovary |
| Bone Antibodies | >1 publications with MXD4 and Bone |
| Testis Antibodies | >1 publications with MXD4 and Testis |
| Brain Antibodies | >1 publications with MXD4 and Brain |