N-Glycolylneuraminic acid [1113-83-3]
Référence T19456-10mg
Conditionnement : 10mg
Marque : TargetMol
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N-Glycolylneuraminic acid
(Synonyms: NeuGc, GcNeu) Copy Product Info
N-Glycolylneuraminic acid (GcNeu) is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.
Cas No. 1113-83-3
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.94%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | N-Glycolylneuraminic acid (GcNeu) is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs. |
| In vitro | Expression of N-Glycolylneuraminic acid on human cells clearly suppressed infectivity of IAVs that possess N-Glycolylneuraminic acid binding ability. Furthermore, there was no difference in infectivity of a transfectant virus that included the wild-type HA gene from A/Memphis/1/1971 (H3N2), which shows no N-Glycolylneuraminic acid binding, between parent MCF7 cells and cells stably expressing the monkey CMAH gene (CMAH-MCF7 cells). On the other hand, cell entry of the transfectant virus that included the N-Glycolylneuraminic acid-binding HA gene with a single mutation to Tyr at position Thr155 was arrested at the stage of internalization from the plasma membrane of the CMAH-MCF7 cells[1]. |
| Synonyms | NeuGc, GcNeu |
| Molecular Weight | 325.27 |
| Formula | C11H19NO10 |
| Cas No. | 1113-83-3 |
| Smiles | OC[C@@H](O)[C@@H](O)[C@@H]1O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O |
| Relative Density. | 1.670 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33.7 mg/mL (103.61 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Saline: 3.37 mg/mL (10.36 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||