NME1 Detection Antibody
Référence OAOA22281
Conditionnement : 50µg
Marque : Aviva Systems Biology
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NME1 Detection Antibody : Biotin (OAOA22281)
| Datasheets/Manuals | Printable datasheet for NME1 Detection Antibody : Biotin (OAOA22281) |
|---|
| Predicted Species Reactivity | Human|Mouse|Rat |
|---|---|
| Product Format | Stored in PBS (pH 7.4) with 0.05% sodium azide, 10mg/ml BSA, 50% glycerol |
| Clonality | Monoclonal |
| Clone | OTI7F2 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | Biotin |
| Application | ELISA |
| Additional Information | Matched ELISA Pair: OAOA21856 |
| Reconstitution and Storage | -20°C |
| Immunogen | Full length human recombinant protein of human NME1 (NM_000269) produced in HEK293T cell. |
| Concentration | 0.5 mg/ml |
| Description | NME1 biotinylated mouse monoclonal detection antibody, validated for ELISA and Luminex assays |
| Gene Symbol | NME1 |
|---|---|
| Gene Full Name | NME/NM23 nucleoside diphosphate kinase 1 |
| Alias Symbols | AWD, epididymis secretory sperm binding protein, GAAD, granzyme A-activated DNase, metastasis inhibition factor nm23, NB, NBS, NDKA, NDP kinase A, NDPK-A, NDPKA, NM23, NM23-H1, non-metastatic cells 1, protein (NM23A) expressed in, nucleoside diphosphate kinase A, tumor metastatic process-associated protein. |
| NCBI Gene Id | 4830 |
| Protein Name | Homo sapiens NME/NM23 nucleoside diphosphate kinase 1 (NME1), transcript variant 2, mRNA|Nucleoside diphosphate kinase A |
| Description of Target | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
| Uniprot ID | P15531 |
| Protein Accession # | NP_000260 |
| Nucleotide Accession # | https://www.ncbi.nlm.nih.gov/nuccore/NM_000269 |
