Oleoyl 3-carbacyclic Phosphatidic Acid [779333-58-3]

Oleoyl 3-carbacyclic Phosphatidic Acid are naturally occurring lysophosphatidic acid (LPA) analogs characterized by a five-membered ring formed between the sn-2 hydroxy group and the sn-3 phosphate moiety. Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) contains the 18:1 fatty acid oleate at the sn-1 position of the glycerol backbone and functions as a cyclic lysophosphatidic acid analog. At a concentration of 25 μM, Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) inhibits MM1 cell transcellular migration through mesothelial cell monolayers induced by fetal bovine serum by 90.1% and by lysophosphatidic acid by 99.9%, without affecting cell proliferation. Furthermore, Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1), at concentrations ranging from 0.1 to 1.0 μM, markedly suppresses autotaxin, a key regulator of cancer cell survival, growth, migration, invasion, and metastasis. These findings support the application of Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) in studies of lysophospholipid signaling, cancer cell biology, cell migration, and autotaxin-mediated molecular mechanisms.