Oleoyl-L-α-lysophosphatidic Acid Sodium Salt [22556-62-3]

Autophagy inhibitor. Oleoyl-L-a-lysophosphatidic acid sodium salt (OLA) is a fatty acid that inhibits the growth of cancer cells. It binds to the cell surface and inhibits the production of growth factors, thereby inhibiting cell proliferation. Oleoyl-L-a-lysophosphatidic acid sodium salt has been shown to inhibit the growth of human cancer cells in vitro by binding to tryptophan fluorescence. The gene product for OLA is expressed in stem cells and its dry weight is approximately 0.5%. Oleoyl-L-α-lysophosphatidic Acid reduces the organ injury caused by endotoxemia in the rat. It may be useful in the treatment of shock of various etiologies.

Synonyms:
[2-hydroxy-3-(octadec-9-enoyloxy)propoxy]phosphonic acid sodium; 1-Oleoyl-sn-glycerol 3-phosphatesodium salt; LPA sodium salt; 3-sn-Lysophosphatidic acid, 1-oleoyl sodium salt

CAS No:
22556-62-3

Molecular Formula:
C21H41O7P•Na

Molecular Weight:
458.5

Purity:
≥98% (NMR)

Appearance:
White to off-white powder

Solubility:
DMSO: 1mg/ml; Water (Warm): 10mg/ml

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.