OTUB1 Detection Antibody
Référence OAOA22254
Conditionnement : 50µg
Marque : Aviva Systems Biology
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OTUB1 Detection Antibody : Biotin (OAOA22254)
| Datasheets/Manuals | Printable datasheet for OTUB1 Detection Antibody : Biotin (OAOA22254) |
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| Predicted Species Reactivity | Human|Rat |
|---|---|
| Product Format | Stored in PBS (pH 7.4) with 0.05% sodium azide, 10mg/ml BSA, 50% glycerol |
| Clonality | Monoclonal |
| Clone | OTI1A6 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | Biotin |
| Application | ELISA|MlpxA |
| Additional Information | Matched ELISA Pair: OAOA21824 |
| Reconstitution and Storage | -20°C |
| Immunogen | Full length human recombinant protein of human OTUB1 (NM_017670) produced in HEK293T cell. |
| Concentration | 0.5 mg/ml |
| Dilution | 1:250 - 1:1000 |
| Description | OTUB1 biotinylated mouse monoclonal detection antibody, validated for ELISA and Luminex assays |
| Gene Symbol | OTUB1 |
|---|---|
| Gene Full Name | OTU deubiquitinase, ubiquitin aldehyde binding 1 |
| Alias Symbols | deubiquitinating enzyme OTUB1, HSPC263, OTB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, OTU domain, ubiquitin aldehyde binding 1, OTU-domain Ubal-binding 1, OTU1, otubain-1, ubiquitin thioesterase OTUB1, ubiquitin-specific protease otubain 1, ubiquitin-specific-processing protease OTUB1. |
| NCBI Gene Id | 55611 |
| Protein Name | Homo sapiens OTU deubiquitinase, ubiquitin aldehyde binding 1 (OTUB1), transcript variant 1, mRNA|Ubiquitin thioesterase OTUB1 |
| Description of Target | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin. |
| Uniprot ID | Q96FW1 |
| Protein Accession # | NP_060140 |
| Nucleotide Accession # | https://www.ncbi.nlm.nih.gov/nuccore/NM_017670 |
