p47 phox Antibody
Référence MBS8583064-0,1mL-PE
Conditionnement : 0.1mL(PE)
Marque : MyBiosource
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P47 Phox (p47phox) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8583064MBS8583064 is an antibody targeting p47phox. Also known as p47 phox Antibody. Reactive in Human, Mouse, Pig, Monkey. Host: Rabbit. Rabbit polyclonal antibody to p47 phox More details
Product Overview
Online Datasheet in PDFProduct Name
p47 phox (p47phox), Polyclonal Antibody
Full Product Name
p47 phox Antibody
Product Gene Name
anti-p47phox antibody
Product Synonym Gene Name
NCF1
Product Synonym Names
NOXO2; SH3PXD1A; Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Pig, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of p47 phox protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
44,652 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (74188309..74203659). Location: 7q11.23
OMIM
233700
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human p47 phox. The exact sequence is proprietary.
Product Categories/Family for anti-p47phox antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-p47phox antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-p47phox antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF/IC: 1:50-1:100
IHC: 1:50-1:200
IF/IC: 1:50-1:100
Other Notes
Small volumes of anti-p47phox antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for p47phox. It may not necessarily be applicable to this product.
NCBI Official Full Name
neutrophil cytosol factor 1
NCBI Official Synonym Full Names
neutrophil cytosolic factor 1
NCBI Official Symbol
NCF1
NCBI Official Synonym Symbols
NCF1A; NOXO2; p47phox; SH3PXD1A
UniProt Protein Name
Neutrophil cytosol factor 1
UniProt Synonym Protein Names
47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox
Protein Family
Neutrophil cytosol factor
UniProt Gene Name
NCF1
UniProt Synonym Gene Names
NOXO2; SH3PXD1A; NCF-1
UniProt Entry Name
NCF1_HUMAN
NCBI Protein Information
neutrophil cytosol factor 1; NCF-1; NCF-47K; p47-phox; nox organizer 2; nox-organizing protein 2; NADPH oxidase organizer 2; 47 kDa neutrophil oxidase factor; neutrophil NADPH oxidase factor 1; SH3 and PX domain-containing protein 1A; 47 kDa autosomal chr
NCBI Summary for p47phox
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]
UniProt Comments for p47phox
p47phox: the 47-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. The holo-oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Contains 2 SH2 domains. Mutations in NCF1, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.
Protein type: EC 1.-.-.-; Oxidoreductase
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: Golgi apparatus; extrinsic to membrane; rough endoplasmic reticulum; cell soma; dendrite; cytosol; NADPH oxidase complex
Molecular Function: protein binding; electron carrier activity; superoxide-generating NADPH oxidase activity; phosphatidylinositol-3,4-bisphosphate binding; SH3 domain binding; phosphoinositide binding
Biological Process: respiratory burst during defense response; respiratory burst; interaction with host; apoptosis; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; leukotriene metabolic process; cell proliferation; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of smooth muscle contraction; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular defense response; innate immune response; response to yeast; vascular endothelial growth factor receptor signaling pathway; protein targeting to membrane; inflammatory response; superoxide release; hydrogen peroxide biosynthetic process
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I
Show more Protein type: EC 1.-.-.-; Oxidoreductase
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: Golgi apparatus; extrinsic to membrane; rough endoplasmic reticulum; cell soma; dendrite; cytosol; NADPH oxidase complex
Molecular Function: protein binding; electron carrier activity; superoxide-generating NADPH oxidase activity; phosphatidylinositol-3,4-bisphosphate binding; SH3 domain binding; phosphoinositide binding
Biological Process: respiratory burst during defense response; respiratory burst; interaction with host; apoptosis; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; leukotriene metabolic process; cell proliferation; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of smooth muscle contraction; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular defense response; innate immune response; response to yeast; vascular endothelial growth factor receptor signaling pathway; protein targeting to membrane; inflammatory response; superoxide release; hydrogen peroxide biosynthetic process
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I
Research Articles on p47phox
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-p47phox antibody
| Reference Product | PubMed Publications |
|---|---|
| CYBB antibody | >25 publications with p47phox and CYBB |
| NCF2 antibody | >19 publications with p47phox and NCF2 |
| CYBA antibody | >15 publications with p47phox and CYBA |
| NCF4 antibody | >6 publications with p47phox and NCF4 |
| RAC1 antibody | >1 publications with p47phox and RAC1 |
| NFKB1 antibody | >1 publications with p47phox and NFKB1 |
Pathways associated with anti-p47phox antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| AGE/RAGE Pathway antibodies | AGE/RAGE Pathway Diagram |
| Chemokine Signaling Pathway antibodies | Chemokine Signaling Pathway Diagram |
| Chemokine Signaling Pathway antibodies | Chemokine Signaling Pathway Diagram |
| Fc Gamma R-mediated Phagocytosis Pathway antibodies | Fc Gamma R-mediated Phagocytosis Pathway Diagram |
| Fc Gamma R-mediated Phagocytosis Pathway antibodies | Fc Gamma R-mediated Phagocytosis Pathway Diagram |
| Leishmaniasis Pathway antibodies | Leishmaniasis Pathway Diagram |
| Leishmaniasis Pathway antibodies | Leishmaniasis Pathway Diagram |
| Leukocyte Transendothelial Migration Pathway antibodies | Leukocyte Transendothelial Migration Pathway Diagram |
| Leukocyte Transendothelial Migration Pathway antibodies | Leukocyte Transendothelial Migration Pathway Diagram |
| Osteoclast Differentiation Pathway antibodies | Osteoclast Differentiation Pathway Diagram |
Diseases associated with anti-p47phox antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >35 publications with p47phox and Inflammation |
| Arthritis, Rheumatoid Antibodies | >23 publications with p47phox and Arthritis, Rheumatoid |
| Heart Diseases Antibodies | >6 publications with p47phox and Heart Diseases |
| Necrosis Antibodies | >5 publications with p47phox and Necrosis |
| Hypertension Antibodies | >4 publications with p47phox and Hypertension |
| Diabetes Mellitus, Experimental Antibodies | >3 publications with p47phox and Diabetes Mellitus, Experimental |
| Hypertrophy Antibodies | >2 publications with p47phox and Hypertrophy |
| Fibrosis Antibodies | >2 publications with p47phox and Fibrosis |
| Hemorrhage Antibodies | >2 publications with p47phox and Hemorrhage |
| Liver Diseases Antibodies | >2 publications with p47phox and Liver Diseases |
Organs/Tissues associated with anti-p47phox antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >40 publications with p47phox and Blood |
| Lymph Node Antibodies | >6 publications with p47phox and Lymph Node |
| Lymph Antibodies | >6 publications with p47phox and Lymph |
| Spleen Antibodies | >5 publications with p47phox and Spleen |
| Lung Antibodies | >5 publications with p47phox and Lung |
| Bone Antibodies | >4 publications with p47phox and Bone |
| Brain Antibodies | >3 publications with p47phox and Brain |
| Connective Tissue Antibodies | >2 publications with p47phox and Connective Tissue |
| Bone Marrow Antibodies | >1 publications with p47phox and Bone Marrow |
| Placenta Antibodies | >1 publications with p47phox and Placenta |