Conditionnement : 10mg
Téléphone : +1 850 650 7790
Synonyms: Ac-(DLeu)LLLRVK-Amba
| Description | PACE4 Inhibitory peptide C23 (Compound C23) is an effective peptidomimetic inhibitor known to act against PACE4. It exhibits antiproliferative effects on PCa cell lines, with a Ki of 5 nM, and IC50 values of 25 μM and 40 μM for DU145 and LNCaP cells, respectively. Additionally, PACE4 Inhibitory peptide C23 suppresses tumor growth in LNCaP xenograft mice. |
| Synonyms | Ac-(DLeu)LLLRVK-Amba |
| Molecular Weight | 1027.35 |
| Formula | C51H90N14O8 |
| Cas No. | 1426656-94-1 |
| Smiles | [C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](CC(C)C)NC(C)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)(C(N[C@H](C(N[C@H](C(NCC1=CC=C(C(=N)N)C=C1)=O)CCCCN)=O)[C@@H](C)C)=O)CCCNC(=N)N |
| Sequence | Ac-{D-Leu}-Leu-Leu-Leu-Arg-Val-Lys-Amba |
| Sequence Short | LLLLRVK |
| Storage | Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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