Paravalbumin Antibody, Clone C12: ATTO 390

Référence MBS8005806-0,1mg

Conditionnement : 0.1mg

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Parvalbumin (PVALB) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8005806

Background: Parvalbumin is involved in calcium signaling. Alterations in the function of parvalbumin-expressing neurons hav been implicated in Alzheimer's, autism, schizophrenia, age-related cognitive defects and some forms of cancer (1). More details

Product Overview

Online Datasheet in PDF
Product Name
Parvalbumin (Pvalb), Monoclonal Antibody
Full Product Name
Paravalbumin Antibody, Clone C12: ATTO 390
Product Gene Name
anti-Pvalb antibody
Product Synonym Names
Mouse Anti-Rat Paravalbumin Monoclonal IgG2a; Parvalbumin alpha antibody; PRVA_HUMAN antibody; PVALB antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
C12
Host
Mouse
Species Reactivity
Rat, Mouse
Form/Format
PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Purity/Purification
Protein A Purified
Concentration
1mg/ml (lot specific)
Specificity
Detects 12 kDa.
Preparation and Storage
Store at -20 degree C
Shipping Temperature: Blue Ice or 4 degree C
3D Structure
ModBase 3D Structure for P02625
Immunogen
Synthetic peptide from the full length Rat Parvalbumin protein
Immunogen Species
Rat
Tissue Specificity
Retina. Expressed throughout the horizontal cells and/or terminals.
Conjugate
ATTO 390
Cellular Localization
Cytoplasmic vesicle membrane
Certificate of Analysis
A 1:500 dilution was sufficient for detection of Parvalbumin in 15 ug of Rat Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Product Categories/Family for anti-Pvalb antibody

Neuroscience; Neurotransmission; Calcium Signaling; Antibodies
Applications Tested/Suitable for anti-Pvalb antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-Pvalb antibody
WB: 1:500

Western Blot (WB) of anti-Pvalb antibody

Western Blot analysis of Rat brain showing detection of Parvalbumin protein using Mouse Anti-Parvalbumin Monoclonal Antibody, Clone C12 (SMC-563). Load: 15 ug. Primary Antibody: Mouse Anti-Parvalbumin Monoclonal Antibody (SMC-563) at 1:500 for 2 hours at RT with shaking. Secondary Antibody: Goat anti-mouse IgG:HRP at 1:4000 for 1 hour at RT with shaking. Color Development: Chemiluminescent for HRP (Moss) for 5 min in RT.
Mouse Anti-PVALB Monoclonal Antibody – Cat# MBS8005806

Product References and Citations for anti-Pvalb antibody

1. Cates. M.S., Teodoro M.L., Phillips G.N. (2002) Biophys J. 82(3): 1133-1146.

Other Notes

Small volumes of anti-Pvalb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pvalb purchase

MBS8005806 is an antibody targeting Pvalb. Also known as Paravalbumin Antibody, Clone C12: ATTO 390. Reactive in Rat, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Pvalb. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
parvalbumin alpha
NCBI Official Synonym Full Names
parvalbumin
NCBI Official Symbol
Pvalb
NCBI Official Synonym Symbols
Pva; PALB1
UniProt Protein Name
Parvalbumin alpha
Protein Family
Parvalbumin
UniProt Gene Name
Pvalb
UniProt Synonym Gene Names
Pva
UniProt Entry Name
PRVA_RAT
NCBI Protein Information
parvalbumin alpha

NCBI Summary for Pvalb

binds two calcium ions; may have evolved from an ancestral four domain calcium binding protein [RGD, Feb 2006]

UniProt Comments for Pvalb

PVA: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Belongs to the parvalbumin family.

Cellular Component: protein complex; cell soma; axon; cytoplasm; terminal button; nucleus

Molecular Function: protein homodimerization activity; protein heterodimerization activity; calcium ion binding

Biological Process: cytosolic calcium ion homeostasis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Pvalb antibody

 Disease Name  Pubmed Publications
 Prenatal Exposure Delayed Effects Antibodies  >4 publications with Pvalb and Prenatal Exposure Delayed Effects
 Nervous System Diseases Antibodies  >4 publications with Pvalb and Nervous System Diseases
 Adenoma, Oxyphilic Antibodies  >2 publications with Pvalb and Adenoma, Oxyphilic
 Carcinoma, Renal Cell Antibodies  >2 publications with Pvalb and Carcinoma, Renal Cell
 Schizophrenia Antibodies  >2 publications with Pvalb and Schizophrenia
 Nervous System Malformations Antibodies  >1 publications with Pvalb and Nervous System Malformations
 Neurobehavioral Manifestations Antibodies  >1 publications with Pvalb and Neurobehavioral Manifestations
 Nerve Degeneration Antibodies  >1 publications with Pvalb and Nerve Degeneration
 Necrosis Antibodies  >1 publications with Pvalb and Necrosis
 Atrophy Antibodies  >1 publications with Pvalb and Atrophy

Organs/Tissues associated with anti-Pvalb antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with Pvalb and Brain
 Muscle Antibodies  >8 publications with Pvalb and Muscle
 Eye Antibodies  >2 publications with Pvalb and Eye
 Ovary Antibodies  >1 publications with Pvalb and Ovary