PathPlus™ CCR7 Antibody (N-Terminus)
Référence LS-A748-50
Conditionnement : 50ul
Marque : LSBio
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Téléphone : +1 850 650 7790
Overview
Antibody:
CCR7 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Chemokine (C-C motif) receptor 7 (CCR7) is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naive T cells. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CCR7
Synonyms
CCR7 | BLR2 | Chemokine (C-C) receptor 7 | CD197 | C-C CKR-7 | CMKBR7 | CC chemokine receptor 7 | CCR-7 | CD197 antigen | CDw197 | EBI1 | EVI1 | MIP-3 beta receptor | C-c chemokine receptor 7 | C-C chemokine receptor type 7 | CC-CKR-7 | Chemokine c-c motif receptor 7
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 17 amino acid peptide from N-Terminus extracellular domain of human CCR7. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Bovine, Horse, Rabbit, Pig (100%); Mouse, Rat, Hamster, Dog, Bat (94%).
Epitope
N-Terminus
Specificity
Human CCR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (5 - 10 µg/ml)
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee About CCR7
P32248 NM_001838 NP_001829.1
Validation
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
tonsil, pericryptal lymphocytes
lymph node, Hodgkin's lymphoma
Anti-CCR7 antibody IHC staining of human tonsil, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CCR7 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CCR7 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Request SDS/MSDS
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