PathPlus™ TJP1 / ZO-1 Antibody (aa1-296)
Référence LS-B11010-50
Conditionnement : 50ul
Marque : LSBio
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Overview
Antibody:
TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa1-296) Antibody
Application:
IHC, IHC-P, ICC, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
TJP1 (Tight junction protein-1, Zonula occludens-1, ZO-1) is a scaffold protein involved in tight junction assembly, anchoring and stabilization. It functions in cell-cell junction signal transduction and in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. TJP1 is upregulated in and drug-resistant multiple myeloma, and is associated with a higher risk subset of cancers. TJP1 has been found to be upregulated in drug-resistant tumors. In immunohistochemistry of normal tissue, TJP1 has membranous positivity in endothelial cells, glandular epithelia, renal glomeruli, sertoli cells, and is expressed in most tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Oncoscience. 2017 Jul; 4(7-8): 79–94, PMID: 28966941
Target
Human TJP1 / ZO-1
Synonyms
TJP1 | ZO-1 | Zona occludens protein 1 | Zona occludens 1 | Zonula occludens protein 1 | Tight junction protein 1 | ZO1 | Tight junction protein ZO-1 | Zonula occludens 1 protein
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human ZO-1. The exact sequence is proprietary.
Epitope
aa1-296
Specificity
Human ZO-1
Applications
- IHC
- IHC - Paraffin (5 - 10 µg/ml)
- ICC (1:100 - 1:1000)
- Western blot (1:500 - 1:3000)
Presentation
1X PBS, pH 7, 0.025% ProClin™ 300, 20% Glycerol
Storage
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee About TJP1 / ZO-1
Q07157 NM_003257 NP_003248.3
Validation
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Anti-TJP1 / ZO-1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
tech@biovalley.fr