PDE6D Antibody

Référence MBS7005086-0,05mg

Conditionnement : 0.05mg

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PDE6D Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7005086

MBS7005086 is an antibody targeting PDE6D. Also known as PDE6D Antibody. Reactive in Human. Host: Rabbit. More details

Product Overview

Online Datasheet in PDF
Product Name
PDE6D, Polyclonal Antibody
Full Product Name
PDE6D Antibody
Product Gene Name
anti-PDE6D antibody
Product Synonym Names
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17), PDE6D, PDED
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: PDE6D (MBS7005086)
HRP Conjugated Antibody: PDE6D (MBS1494125)
Matching Pairs
Unconjugated Antibody: PDE6D (MBS7005086)
Biotin Conjugated Antibody: PDE6D (MBS1495284)
OMIM
602676
3D Structure
ModBase 3D Structure for O43924
Immunogen
Recombinant Human Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta protein (1-150AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Research Area
Signal Transduction
Target Names
PDE6D
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PDE6D antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PDE6D antibody
WB:1:500-1:2000
IHC:1:20-1:200

Western Blot (WB) of anti-PDE6D antibody

Western blot
All lanes: PDE6D antibody at 1.5ug/ml
Lane 1: A549 whole cell lysate
Lane 2: MCF-7 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 18 kDa
Observed band size: 18 kDa
Rabbit Anti-PDE6D Polyclonal Antibody – Cat# MBS7005086

Immunohistochemistry (IHC) of anti-PDE6D antibody

Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7005086 at dilution of 1:100
Rabbit Anti-PDE6D Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7005086

Other Notes

Small volumes of anti-PDE6D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE6D. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 2
NCBI Official Synonym Full Names
phosphodiesterase 6D
NCBI Official Symbol
PDE6D
NCBI Official Synonym Symbols
PDED; JBTS22
UniProt Protein Name
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
UniProt Synonym Protein Names
Protein p17
Protein Family
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase
UniProt Gene Name
PDE6D
UniProt Synonym Gene Names
PDED; GMP-PDE delta
UniProt Entry Name
PDE6D_HUMAN
NCBI Protein Information
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

NCBI Summary for PDE6D

This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]
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UniProt Comments for PDE6D

PDE6D: Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation. Belongs to the PDE6D/unc-119 family.

Chromosomal Location of Human Ortholog: 2q35-q36

Cellular Component: cytoplasmic vesicle; cytoplasmic vesicle membrane; cytoskeleton; cytosol

Molecular Function: 3',5'-cyclic-nucleotide phosphodiesterase activity; GTPase inhibitor activity; protein binding; Rab GTPase binding

Biological Process: metabolic process; organelle organization and biogenesis; response to stimulus; visual perception

Disease: Joubert Syndrome 22
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDE6D antibody

 Reference Product  PubMed Publications
 ARL3 antibody  >7 publications with PDE6D and ARL3
 ARL2 antibody  >5 publications with PDE6D and ARL2
 RPGR antibody  >4 publications with PDE6D and RPGR
 RHEB antibody  >1 publications with PDE6D and RHEB

Pathways associated with anti-PDE6D antibody

 Products by Pathway  Pathway Diagram
 ARL13B-mediated Ciliary Trafficking Of INPP5E Pathway antibodies  ARL13B-mediated Ciliary Trafficking Of INPP5E Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with anti-PDE6D antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with PDE6D and Disease Models, Animal
 Atrophy Antibodies  >3 publications with PDE6D and Atrophy
 Nervous System Diseases Antibodies  >1 publications with PDE6D and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with PDE6D and Kidney Diseases

Organs/Tissues associated with anti-PDE6D antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >16 publications with PDE6D and Eye
 Brain Antibodies  >3 publications with PDE6D and Brain
 Lung Antibodies  >2 publications with PDE6D and Lung
 Kidney Antibodies  >2 publications with PDE6D and Kidney
 Spleen Antibodies  >1 publications with PDE6D and Spleen
 Liver Antibodies  >1 publications with PDE6D and Liver

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MBS7005086-5x0,1mg
 5x0.1mg 
MBS7005086-0,1mg
 0.1mg