Pladienolide B [445493-23-2]
Référence T16551-100ug
Conditionnement : 100ug
Marque : TargetMol
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Pladienolide B
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Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors.
Cas No. 445493-23-2
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.27%
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors. |
| In vitro | Pladienolide B (0.1-2 nM; 24-72 h; HeLa cells) decreases SF3b1 expression, induces cell cycle arrest and apoptosis, and suppresses cell viability in human cervical carcinoma cells in a concentration- and time-dependent manner. [3] |
| In vivo | Pladienolide B (2.5-10 mg/kg; i.v.; daily for 5 days) demonstrated strong growth inhibitory or regressive activities against PC-3, OVCAR-3, DU-145, WiDr, and HCT-116, BSY-1 xenografts in BALB/c nu/nu mice, exhibiting intense antitumor activities.[4] |
| Molecular Weight | 536.7 |
| Formula | C30H48O8 |
| Cas No. | 445493-23-2 |
| Smiles | C([C@@H](/C=C/C=C(\C)/[C@@H]1[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)CC(=O)O1)C)[C@@H]2[C@@]([C@@H]([C@H](CC)O)C)(O2)05 |
| Relative Density. | 1.13 g/cm3 (Predicted) |
| Storage | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |