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> Posaconazole

Posaconazole

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Référence 286988-5g

Conditionnement : 5g

Marque : US Biological

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286988 Posaconazole

Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Anti-fungal agent; sterol α-demethylase inhibitor. Posaconazole is a highly potent broadspectrum antifungal drug. It blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase resulting in accumulation of methylated sterol precursors. In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole was able to produce a parasitological cure in a mouse model of the chronic stage of Chagas disease.

Synonyms:
2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol; Noxafil; Sch 56592

CAS No:
171228-49-2

Molecular Formula:
C₃₇H₄₂F₂N₈O₄

Molecular Weight:
700.78

Purity:
≥98%

Appearance:
White to off-white powder

Melting Point:
166-168°C (lit)

Specific Rotation (C=1 CHCL3):
As Reported

Storage and Stability:
Store at -20ºC. Stable for 6 months after receipt.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Cacciapuoti, A., et al.: Antimicrob. Agents Chemother., 44, 2017 (2000). 2. Herbrecht, R., et al.: Int. J. Clin. Pract., 58, 612 (2004). 3. Panackal, A., et al.: J. Clin. Microbiol., 44, 1740 (2006). 4. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole J. Antimicrob. Chemother. 56 (Suppl 1), i39-i48 (2005). 5. Munayyer, H.K., Mann, P.A., Chau, A.S., et al. Posaconazole is a potent inhibitor of sterol 14α-demethylation in yeasts and molds Antimicrobial Agents and Chemotherapy 48(10), 3690-3696 (2004).