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Quinacrine dihydrochloride [69-05-6]

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Référence NB-64-01103-500mg

Conditionnement : 500mg

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Quinacrine dihydrochloride

(Synonyms: SN-390, Quinacrine 2HCl, Mepacrine dihydrochloride) Copy Product Info

Synonyms: SN-390, Quinacrine 2HCl, Mepacrine dihydrochloride

Catalog No. T0942 Copy Product Info

Purity: 99.80%

Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.

Cas No. 69-05-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.80%

Color:Yellow

Product Introduction

Quinacrine dihydrochloride AI Summary

Quinacrine dihydrochloride exhibits a range of bioactivities across various biological systems. It shows significant cytotoxic effects on cultured MT-4 and HepG2 lymphocytes, with decreasing cell viability at increasing concentrations and an IC50 value of 1100.0 nM in HepG2 cells. It also demonstrates cytotoxicity in human peripheral blood monocyte cells with an IC50 value of 2150.0 nM. This compound effectively inhibits HIV-1 induced cytopathic effects in MT-4 lymphocytes at 100 ug/mL and shows potent antiplasmodial activity against Plasmodium falciparum strains, with IC50 values ranging from 0.08 to 1.0 nM. Additionally, Quinacrine dihydrochloride binds to human AAG and ORM2, with binding affinities of Ka = 2.3 x 10^5/M and Ka = 3.7 x 10^5/M, respectively, and also to calf thymus DNA, indicated by a melting temperature of 88.0 degrees Celsius at a concentration of 10^-5 M. Moreover, it inhibits multiple targets including Menin-MLL interaction in leukemia, DNA helicases, HSD17B4, and JMJD2E. Its versatile bioactivity extends to modulating splicing processes, histone interactions, DNA re-replication, cytochrome activity, viral entry, tau fibril formation, and hemoglobin splicing, indicating its potential across diverse molecular pathways and cellular functions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
Synonyms	SN-390, Quinacrine 2HCl, Mepacrine dihydrochloride

Chemical Properties

Molecular Weight	472.88
Formula	C₂₃H₃₀CLN₃O·2HCl
Cas No.	69-05-6
Smiles	CCN(CC)CCCC(C)Nc1c2ccc(cc2nc2c1cc(cc2)OC)Cl.Cl.Cl
Relative Density.	1.2962 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 49 mg/mL (103.62 mM), Sonication is recommended.

DMSO: 4.73 mg/mL (10 mM), Sonication is recommended.

Ethanol: 27 mg/mL (57.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1147 mL	10.5735 mL	21.1470 mL	105.7351 mL
5 mM	0.4229 mL	2.1147 mL	4.2294 mL	21.1470 mL
10 mM	0.2115 mL	1.0574 mL	2.1147 mL	10.5735 mL

Ethanol/H2O

	1mg	5mg	10mg	50mg
20 mM	0.1057 mL	0.5287 mL	1.0574 mL	5.2868 mL
50 mM	0.0423 mL	0.2115 mL	0.4229 mL	2.1147 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0211 mL	0.1057 mL	0.2115 mL	1.0574 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

SN390SN 390SGC-7901Quinacrine dihydrochlorideQuinacrinePLCLPPLA2Parasitep53myeloidMitophagyMitochondrial AutophagyMepacrine DihydrochlorideMepacrineleukemiaInhibitorinhibitHistamineReceptorHistamine Receptorhistamine N-methyl transferaseDNABcl-2BaxAutophagyApoptosisAcute

Related Tags: Quinacrine dihydrochloride chemical structure | Quinacrine dihydrochloride formula | Quinacrine dihydrochloride molecular weight