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> Rabbit Anti-TOB1 (N-term) Polyclonal Antibody

Rabbit Anti-TOB1 (N-term) Polyclonal Antibody

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Référence AP8571a

Conditionnement : 400ul

Marque : Abcepta

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TOB1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

 
  • WB - TOB1 Antibody (N-term) AP8571a

    Western blot analysis of TOB1 Antibody (N-term) (Cat. #AP8571a) in mouse liver tissue lysates (35ug/lane). TOB1 (arrow) was detected using the purified Pab.

  • IHC-P - TOB1 Antibody (N-term) AP8571a

    Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with TOB1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

  • FC - TOB1 Antibody (N-term) AP8571a

    TOB1 Antibody (N-term) (Cat. #AP8571a) flow cytometric analysis of NCI-H292 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Western blot analysis of TOB1 Antibody (N-term) (Cat. #AP8571a) in mouse liver tissue lysates (35ug/lane). TOB1 (arrow) was detected using the purified Pab.

Product Information

Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, IHC-P, WB, E
Primary Accession P50616
Other Accession Q8R5K6, Q61471
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 38155 Da
Antigen Region 54-83 aa

Additional Information

Gene ID 10140
Other Names Protein Tob1, Transducer of erbB-2 1, TOB1, TOB, TROB1
Target/Specificity This TOB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human TOB1.
Dilution FC~~1:10~50
IHC-P~~1:50~100
WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTOB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information

Name TOB1
Synonyms TOB, TROB1
Function Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).
Cellular Location Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S- phase where more than half of proteins become cytoplasmic
Tissue Location Ubiquitous.
Research Areas
  • Primary Antibodies
  • Cancer
  • Signal Transduction

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