Rabbit Monoclonal Anti-Phospho-Shp1 (Y536) [Clone Shp1Y536-2A7]

Src homology-2 domain containing phosphatase-1 (Shp1) typically functions as a negative regulator for signal transduction, interacting with Zap70, CD5, CD3ε, and IL-2R in T cells. Shp1 suppresses cellular signaling by dephosphorylating target proteins. Shp1 is expressed predominantly in hematopoietic cells, where it can plays a role in malignant transformation into cancer cells. Methylation of the Shp1 promoter has been shown to silence Shp1 expression and promote the development of cancer. Shp1 negatively regulates PDGF and insulin tyrosine receptor pathways, and negatively regulates Lck in the TCR signaling pathway to limit TCR responsiveness. Shp1 activity is prevented by TAOK3 in T cells to allow for T cell activation and differentiation.