Rat PFKL (Phosphofructokinase, Liver) Sandwich ELISA Kit E0011414)

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Pfkl
Gene ID:	25741
Uniprot ID:	PFKAL_RAT
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation.
Function	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.
Protein Name	Atp-Dependent 6-Phosphofructokinase - Liver Type Atp-Pfk Pfk-L 6-Phosphofructokinase Type B Phosphofructo-1-Kinase Isozyme B Pfk-B Phosphohexokinase
Database Links	Reactome: R-RNO-6798695 Reactome: -RNO-70171
Cellular Localisation	Cytoplasm
Alternative ELISA Names	Atp-Dependent 6-Phosphofructokinase - Liver Type ELISA kit Atp-Pfk ELISA kit Pfk-L ELISA kit 6-Phosphofructokinase Type B ELISA kit Phosphofructo-1-Kinase Isozyme B ELISA kit Pfk-B ELISA kit Phosphohexokinase ELISA kit Pfkl ELISA kit Pfk-l ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance