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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

RO-0335 [867365-76-2]

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Référence NB-64-45563-25mg

Conditionnement : 25mg

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RO-0335

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Synonyms:

Catalog No. T9223 Copy Product Info

Purity: 99.53%

RO-0335 is a potent diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 (IC₅₀ = 1.1 nM) and retained activity (IC₅₀< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates.

Cas No. 867365-76-2

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.53%

Appearance:Solid

Color:White

Product Introduction

RO-0335 AI Summary

RO-0335 has a half-life of over 120 hours when administered orally at a dosage of 20 to 40 mg for 7 days in humans infected with HIV. It exhibits antiviral activity against HIV1, with an EC50 value of 13.8 nM when assessed as serum adjusted potency and an EC50 value of 1.2 nM in general antiviral activity testing..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RO-0335 is a potent diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 (IC₅₀ = 1.1 nM) and retained activity (IC₅₀< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates.

Chemical Properties

Molecular Weight	573.22
Formula	C₂₁H₁₃BrCl₂FN₃O₄S
Cas No.	867365-76-2
Smiles	NS(=O)(=O)c1ccc(NC(=O)Cc2ccc(Br)c(Oc3cc(Cl)cc(c3)C#N)c2F)c(Cl)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 140 mg/mL (244.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.72 mM), Sonication is recommended.

10% DMSO+90% Saline: 10 mg/mL (17.45 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7445 mL	8.7227 mL	17.4453 mL	87.2265 mL
5 mM	0.3489 mL	1.7445 mL	3.4891 mL	17.4453 mL
10 mM	0.1745 mL	0.8723 mL	1.7445 mL	8.7227 mL
20 mM	0.0872 mL	0.4361 mL	0.8723 mL	4.3613 mL
50 mM	0.0349 mL	0.1745 mL	0.3489 mL	1.7445 mL
100 mM	0.0174 mL	0.0872 mL	0.1745 mL	0.8723 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

RO-0335RO0335RO 0335ReverseTranscriptaseReverse TranscriptasepotentnovelnonnucleosideInhibitorinhibitHIV-1diphenylether

Related Tags: RO-0335 chemical structure | RO-0335 formula | RO-0335 molecular weight