ROBO2 Antibody
Référence MBS8582381-0,1mL-PE
Conditionnement : 0.1mL(PE)
Marque : MyBiosource
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ROBO2 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582381MBS8582381 is an antibody targeting ROBO2. Also known as ROBO2 Antibody. Reactive in Human, Mouse, Rat, Bovine, Chicken. Host: Rabbit. Rabbit polyclonal antibody to ROBO2 More details
Product Overview
Online Datasheet in PDFProduct Name
ROBO2, Polyclonal Antibody
Full Product Name
ROBO2 Antibody
Product Gene Name
anti-ROBO2 antibody
Product Synonym Names
KIAA1568; Roundabout homolog 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Chicken
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of ROBO2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
151,200 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (75955845..77699115). Location: 3p12.3
OMIM
602431
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ROBO2. The exact sequence is proprietary.
Product Categories/Family for anti-ROBO2 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ROBO2 antibody
Western Blot (WB)
Application Notes for anti-ROBO2 antibody
WB: 1:500-1:1000
Other Notes
Small volumes of anti-ROBO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for ROBO2. It may not necessarily be applicable to this product.
NCBI Official Full Name
roundabout homolog 2 isoform ROBO2a
NCBI Official Synonym Full Names
roundabout, axon guidance receptor, homolog 2 (Drosophila)
NCBI Official Symbol
ROBO2
NCBI Official Synonym Symbols
SAX3
UniProt Protein Name
Roundabout homolog 2
Protein Family
Roundabout
UniProt Gene Name
ROBO2
UniProt Synonym Gene Names
KIAA1568
UniProt Entry Name
ROBO2_HUMAN
NCBI Protein Information
roundabout homolog 2
NCBI Summary for ROBO2
This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for ROBO2
ROBO2: Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2). VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults. A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT- ROBO signaling in vitro. Belongs to the immunoglobulin superfamily. ROBO family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Cell development/differentiation
Chromosomal Location of Human Ortholog: 3p12.3
Cellular Component: cell surface; integral to membrane; axolemma
Molecular Function: identical protein binding; protein binding; axon guidance receptor activity
Biological Process: axon guidance; central nervous system development; olfactory bulb interneuron development; negative regulation of synaptogenesis; axon midline choice point recognition; cellular response to hormone stimulus; negative regulation of negative chemotaxis; ureteric bud development; positive regulation of axonogenesis; brain development; homophilic cell adhesion; metanephros development; retinal ganglion cell axon guidance
Disease: Vesicoureteral Reflux 2
Show more Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Cell development/differentiation
Chromosomal Location of Human Ortholog: 3p12.3
Cellular Component: cell surface; integral to membrane; axolemma
Molecular Function: identical protein binding; protein binding; axon guidance receptor activity
Biological Process: axon guidance; central nervous system development; olfactory bulb interneuron development; negative regulation of synaptogenesis; axon midline choice point recognition; cellular response to hormone stimulus; negative regulation of negative chemotaxis; ureteric bud development; positive regulation of axonogenesis; brain development; homophilic cell adhesion; metanephros development; retinal ganglion cell axon guidance
Disease: Vesicoureteral Reflux 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-ROBO2 antibody
| Reference Product | PubMed Publications |
|---|---|
| ROBO1 antibody | >72 publications with ROBO2 and ROBO1 |
| SLIT2 antibody | >62 publications with ROBO2 and SLIT2 |
| SLIT3 antibody | >28 publications with ROBO2 and SLIT3 |
Pathways associated with anti-ROBO2 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| Developmental Biology Pathway antibodies | Developmental Biology Pathway Diagram |
| Regulation Of Commissural Axon Pathfinding By Slit And Robo Pathway antibodies | Regulation Of Commissural Axon Pathfinding By Slit And Robo Pathway Diagram |
| Signaling By Robo Receptor Pathway antibodies | Signaling By Robo Receptor Pathway Diagram |
Diseases associated with anti-ROBO2 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Vesico-Ureteral Reflux Antibodies | >9 publications with ROBO2 and Vesico-Ureteral Reflux |
| Nervous System Diseases Antibodies | >6 publications with ROBO2 and Nervous System Diseases |
| Congenital Abnormalities Antibodies | >5 publications with ROBO2 and Congenital Abnormalities |
| Abnormalities, Multiple Antibodies | >2 publications with ROBO2 and Abnormalities, Multiple |
| Disease Models, Animal Antibodies | >2 publications with ROBO2 and Disease Models, Animal |
| Liver Diseases Antibodies | >2 publications with ROBO2 and Liver Diseases |
| Schizophrenia Antibodies | >2 publications with ROBO2 and Schizophrenia |
| Nerve Degeneration Antibodies | >1 publications with ROBO2 and Nerve Degeneration |
| Abnormalities, Drug-Induced Antibodies | >1 publications with ROBO2 and Abnormalities, Drug-Induced |
| Hypertension Antibodies | >1 publications with ROBO2 and Hypertension |
Organs/Tissues associated with anti-ROBO2 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >72 publications with ROBO2 and Brain |
| Embryonic Tissue Antibodies | >53 publications with ROBO2 and Embryonic Tissue |
| Eye Antibodies | >23 publications with ROBO2 and Eye |
| Muscle Antibodies | >9 publications with ROBO2 and Muscle |
| Vascular Antibodies | >6 publications with ROBO2 and Vascular |
| Heart Antibodies | >5 publications with ROBO2 and Heart |
| Ovary Antibodies | >3 publications with ROBO2 and Ovary |
| Connective Tissue Antibodies | >2 publications with ROBO2 and Connective Tissue |
| Lung Antibodies | >2 publications with ROBO2 and Lung |
| Uterus Antibodies | >1 publications with ROBO2 and Uterus |