Sarcosine [107-97-1]
Référence T6975-2g
Conditionnement : 2g
Marque : TargetMol
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Sarcosine
(Synonyms: Sarcosinic acid, Sarcosin, N-methylglycine, N-Methylaminoacetic acid, Methylglycine, Methylaminoacetic acid) Copy Product Info
Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
Cas No. 107-97-1
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.90%
Appearance:Solid
Color:White
COA HPLC HNMR LCMS
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist. |
| In vitro | Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist[1]. The viability of the sarcosine-treated cells is significantly reduced[4]. |
| In vivo | Sarcosine has weak anticonvulsant properties[2]. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice[3]. |
| Synonyms | Sarcosinic acid, Sarcosin, N-methylglycine, N-Methylaminoacetic acid, Methylglycine, Methylaminoacetic acid |
| Cell Research | Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference) |
| Molecular Weight | 89.09 |
| Formula | C3H7NO2 |
| Cas No. | 107-97-1 |
| Smiles | CNCC(O)=O |
| Relative Density. | 1.093 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 250 mg/mL (2806.15 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||