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> SFRS3 (SRSF3) Rabbit Polyclonal Antibody

SFRS3 (SRSF3) Rabbit Polyclonal Antibody

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SFRS3 (SRSF3) Rabbit Polyclonal Antibody

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SKU
AP01175PU-N
SFRS3 (SRSF3) rabbit polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
 

View other "SRSF3 or NP_003008.1" antibodies

Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution Western Blot: 1/500-1/1000.
Immunofluorescence: 1/50-1/200.
Immunohistochemistry on Paraffin sections: 1/50-1/200.
Reactivity Human, Mouse
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 120-170 of Human SRp20.
Specificity This antibody detects endogenous levels of SFRS3 protein (region surrounding Phe151).
Buffer PBS with 0.02% Sodium Azide, 50% glycerol, pH7.2
Concentration 1.0 mg/ml
Purification Affinity chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE).
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Shipping Blue Ice
Predicted Protein Size ~ 25 kDa
Gene Name serine/arginine-rich splicing factor 3
Database Link
Background Pre-mRNA splicing enhancer elements are short RNA sequences capable of activating weak splice sites in nearby introns that are required for accurate splice site recognition and the control of alternative splicing. Splicing enhancer elements contain specific binding sites for serine/arginine (SR)-rich splicing factors, which include SC35, 9G8, SRp20, and SF2/ASF. The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/ serine(RS)-rich domain. They are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. The majority of SR proteins, including SC35 and SRp40, are confined to the nucleus, while SF2/ASF, SRp20, and 9G8 are continuously shuttled between the nucleus and the cytoplasm and contribute to mRNA transport. The activity of SR proteins in regulated splicing is antagonized by members of the hnRNP A/B family of proteins, which induce drastic shifts in the selection of splicing sites. An additional SR-associated protein, p32, tightly associates with SR factors and preferentially inhibits ASF/SF2 functioning as both a splicing enhancer and splicing repressor protein by preventing the stable interaction of ASF/SF2 and RNA.
Synonyms SRP20
Reference Data
Protein Categories Intracellular Proteins
Product Manuals
FAQs
  • Antibody and Western Standard
SDS

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